Micro-MRI Study of Cerebral Aging: Ex Vivo Detection of Hippocampal Subfield Reorganization, Microhemorrhages and Amyloid Plaques in Mouse Lemur Primates

Abstract : Mouse lemurs are non-human primate models of cerebral aging and neurodegeneration. Much smaller than other primates, they recapitulate numerous features of human brain aging, including progressive cerebral atrophy and correlation between regional atrophy and cognitive impairments. Characterization of brain atrophy in mouse lemurs has been done by MRI measures of regional CSF volume and by MRI measures of regional atrophy. Here, we further characterize mouse lemur brain aging using ex vivo MR microscopy (31 mm in-plane resolution). First, we performed a non-biased, direct volumetric quantification of dentate gyrus and extended Ammon's horn. We show that both dentate gyrus and Ammon's horn undergo an age-related reorganization leading to a growth of the dentate gyrus and an atrophy of the Ammon's horn, even in the absence of global hippocampal atrophy. Second, on these first MR microscopic images of the mouse lemur brain, we depicted cortical and hippocampal hypointense spots. We demonstrated that their incidence increases with aging and that they correspond either to amyloid deposits or to cerebral microhemorrhages.
Complete list of metadatas

Cited literature [54 references]  Display  Hide  Download

https://hal.inria.fr/hal-01407046
Contributor : Anne Bertrand <>
Submitted on : Thursday, December 1, 2016 - 5:50:18 PM
Last modification on : Thursday, July 11, 2019 - 2:10:08 PM
Long-term archiving on : Monday, March 20, 2017 - 11:41:07 PM

File

2013b Bertrand.pdf
Publisher files allowed on an open archive

Identifiers

Citation

Anne Bertrand, Adrien Pasquier, Alexandra Petiet, Christopher Wiggins, Audrey Kraska, et al.. Micro-MRI Study of Cerebral Aging: Ex Vivo Detection of Hippocampal Subfield Reorganization, Microhemorrhages and Amyloid Plaques in Mouse Lemur Primates. PLoS ONE, Public Library of Science, 2013, 8, ⟨10.1371/journal.pone.0056593.g002⟩. ⟨hal-01407046⟩

Share

Metrics

Record views

568

Files downloads

222