Programmes biochimiques et algorithmes mixtes analogiques-digitaux dans la cellule

Abstract : In this chapter we take an IT perspective in seeking to understand how computation is carried out in the cell to maintain itself in its environment, process signals and make the decisions that determine its fate. The continuous nature of many protein interactions leads us to consider mixed analog-digital computation models, for which recent results in the theory of analog computability and complexity establish fundamental links with classical programming. We derive from these results a compiler of behavioural specifications into biochemical reactions which can be compared to natural circuits acquired through evolution. We illustrate this approach through the example of the MAPK signaling module which has a function of analog-digital converter in the cell, and through the cell cycle control.
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Contributor : François Fages <>
Submitted on : Tuesday, May 16, 2017 - 3:16:56 PM
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François Fages, Guillaume Le Guludec. Programmes biochimiques et algorithmes mixtes analogiques-digitaux dans la cellule. Thierry Gaudin; Dominique Lacroix; Marie-Christine Maurel; Jean-Charles Pomerol. Sciences de la vie, sciences de l’information, ⟨ISTE editions⟩, 2017, Colloque de Cérisy, 978-1-78405-287-4. ⟨hal-01409743v3⟩

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