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A non-parametric procedure for co-localization studies in fluorescence microscopy

Abstract : Spatial proximity between proteins is a potential evidence of their interaction. Modern light microscopy associated with fluorescence molecule tagging allow to acquire images with two or more distinct proteins at the same time to characterize the joint spatial repartition and the spatial overlap between them. This analysis is commonly called a « co-localization » study. We propose a non-parametric testing procedure for co-localization based on the overlapping areas defined by the segmented proteins. This procedure is more powerful than existing methods to detect co-localization. In addition, this testing procedure is robust to protein shapes and sizes.
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https://hal.inria.fr/hal-01416844
Contributor : Charles Kervrann <>
Submitted on : Wednesday, December 14, 2016 - 9:51:56 PM
Last modification on : Wednesday, April 11, 2018 - 1:57:28 AM

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  • HAL Id : hal-01416844, version 1

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Thierry Pécot, Frédéric Lavancier, Charles Kervrann. A non-parametric procedure for co-localization studies in fluorescence microscopy. Workshop SSIAB - Spatial Statistics and Image Analysis in Biology, May 2016, Rennes, France. ⟨hal-01416844⟩

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