Microscopic Modelling of the Non-Linear Gap Junction Channels

Anđela Davidović 1, 2, 3, 4 Yves Coudière 2, 4, 1 Thomas Desplantez 3 Clair Poignard 2, 5, 1
4 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
IHU-LIRYC, IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest
5 MONC - Modélisation Mathématique pour l'Oncologie
IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest, Institut Bergonié - CRLCC Bordeaux
Abstract : The usual way to model the propagation of the action potential through the cardiac tissue is to assume passive diffusive intracellular and extracellular domains, and ion channel dynamics on the cells' membrane. Gap junctions (GJ) are localised clusters of gap junction channels (GJCs) that connects electrically adjacent cells. The importance of GJCs and their modifications in the signal propagation has been demonstrated in the experimental studies (e.g. Beauchamp et al 2012). But, in the current mathematical models the behaviour of the GJCs is either neglected or assumed to be passive, i.e the conductance of GJCs is taken as a steady constant. On the other hand, the experimental results, obtained by the dual-voltage clamp technique, show that GJCs are time and voltage dependent. Here we focus on describing ventricular GJCs made of connexin Cx43 and Cx45. We use the Hodgkin-Huxley formalism to describe GJC conductance via one gating variable. We incorporate the non-linear GJC voltage dependence into the microscopic model of the tissue as a new boundary condition on specific parts of the cells' membranes .
Type de document :
Poster
2015 Computing in Cardiology Conference, Sep 2015, Nice, France
Liste complète des métadonnées

Littérature citée [4 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-01418665
Contributeur : Andjela Davidovic <>
Soumis le : vendredi 16 décembre 2016 - 18:16:21
Dernière modification le : mardi 1 mai 2018 - 18:50:03
Document(s) archivé(s) le : mardi 21 mars 2017 - 03:15:09

Fichier

main.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : hal-01418665, version 1

Collections

Citation

Anđela Davidović, Yves Coudière, Thomas Desplantez, Clair Poignard. Microscopic Modelling of the Non-Linear Gap Junction Channels. 2015 Computing in Cardiology Conference, Sep 2015, Nice, France. 〈hal-01418665〉

Partager

Métriques

Consultations de la notice

407

Téléchargements de fichiers

19