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Creation of Three-dimensional Liver Tissue Models from Experimental Images for Systems Medicine

Abstract : In this chapter, we illustrate how three-dimensional liver tissue models can be created from experimental image modalities by utilizing a well-established processing chain of experiments, microscopic imaging, image processing, image analysis and model construction. We describe how key features of liver tissue architecture are quantified and translated into model parameterizations, and show how a systematic iteration of experiments and model simulations often leads to a better understanding of biological phenomena in systems biology and systems medicine.
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https://hal.inria.fr/hal-01426722
Contributor : Dirk Drasdo <>
Submitted on : Wednesday, January 4, 2017 - 6:38:38 PM
Last modification on : Friday, March 27, 2020 - 3:10:41 AM

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Stefan Hoehme, Adrian Friebel, Seddik Hammad, Dirk Drasdo, Jan G. Hengstler. Creation of Three-dimensional Liver Tissue Models from Experimental Images for Systems Medicine. Peggy Stock, Bruno Christ. Hepatocyte Transplantation, 1506, Springer, pp.319-362, 2016, Methods in Molecular Biology, 978-1-4939-6504-5 (Print) 978-1-4939-6506-9. ⟨10.1007/978-1-4939-6506-9_22⟩. ⟨hal-01426722⟩

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