W. Abelmann, Classification and natural history of primary myocardial disease, Progress in Cardiovascular Diseases, vol.27, issue.2, pp.73-94, 1984.
DOI : 10.1016/0033-0620(84)90020-3

R. Abraham, V. Moskvina, and R. Sims, A genome-wide association study for late-onset Alzheimer's disease using DNA pooling, BMC Medical Genomics, vol.21, issue.2, p.44, 2008.
DOI : 10.1093/bioinformatics/bth457

B. Andersson and C. Sylven, The DD genotype of the angiotensin-converting enzyme gene is associated with increased mortality in idiopathic heart failure, Journal of the American College of Cardiology, vol.28, issue.1, pp.162-169, 1996.
DOI : 10.1016/0735-1097(96)00098-8

E. Arbustini, M. Diegoli, and R. Fasani, Mitochondrial DNA Mutations and Mitochondrial Abnormalities in Dilated Cardiomyopathy, The American Journal of Pathology, vol.153, issue.5, pp.1501-1511, 1998.
DOI : 10.1016/S0002-9440(10)65738-0

T. Arimura, T. Hayashi, and H. Terada, A Cypher/ZASP Mutation Associated with Dilated Cardiomyopathy Alters the Binding Affinity to Protein Kinase C, Journal of Biological Chemistry, vol.279, issue.8, pp.6746-52, 2004.
DOI : 10.1074/jbc.M311849200

T. Arimura, Y. Hayashi, and T. Murakami, Mutational Analysis of Fukutin Gene in Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy, Circulation Journal, vol.73, issue.1, 2009.
DOI : 10.1253/circj.CJ-08-0722

T. Arimura, T. Ishikawa, S. Nunoda, S. Kawai, and A. Kimura, mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes, Human Mutation, vol.32, issue.12, pp.1481-91, 2011.
DOI : 10.1002/humu.21603

T. Arimura, Y. Matsumoto, and O. Okazaki, Structural analysis of obscurin gene in hypertrophic cardiomyopathy, Biochemical and Biophysical Research Communications, vol.362, issue.2, pp.281-288, 2007.
DOI : 10.1016/j.bbrc.2007.07.183

T. Arimura, T. Nakamura, and S. Hiroi, Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathy, Human Genetics, vol.107, issue.5, pp.440-51, 2000.
DOI : 10.1007/s004390000389

A. Arola, X. Sanchez, and R. Murphy, Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy, Molecular Genetics and Metabolism, vol.90, issue.4, pp.435-475, 2007.
DOI : 10.1016/j.ymgme.2006.12.008

S. Barbaux, D. Tregouet, and V. Nicaud, Polymorphisms in 33 inflammatory genes and risk of myocardial infarction???a system genetics approach, Journal of Molecular Medicine, vol.109, issue.11, pp.1271-80, 2007.
DOI : 10.1007/s00109-007-0234-x

S. Barbaux, S. Blankenberg, and H. Rupprecht, Association Between P-Selectin Gene Polymorphisms and Soluble P-Selectin Levels and Their Relation to Coronary Artery Disease, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.21, issue.10, pp.1668-73, 2001.
DOI : 10.1161/hq1001.097022

M. Bienengraeber, T. Olson, and V. Selivanov, ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating, Nature Genetics, vol.36, issue.4, pp.382-389, 2004.
DOI : 10.1038/ng1329

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995438

S. Bione, D. Adamo, P. Maestrini, E. Gedeon, A. Bolhuis et al., A novel X-linked gene, G4.5. is responsible for Barth syndrome, Nature Genetics, vol.230, issue.4, pp.385-394, 1996.
DOI : 10.1016/0968-0004(86)90007-1

M. Borjesson, Y. Magnusson, A. Hjalmarson, and B. Andersson, A novel polymorphism in the gene coding for the beta1-adrenergic receptor associated with survival in patients with heart failure, European Heart Journal, vol.21, issue.22, pp.1853-1861, 2000.
DOI : 10.1053/euhj.1999.1994

Y. Bosse, F. Bacot, and A. Montpetit, Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans, Human Genetics, vol.116, issue.Suppl, pp.305-323, 2009.
DOI : 10.1007/s00439-009-0626-9

K. Brauch, M. Karst, and K. Herron, Mutations in Ribonucleic Acid Binding Protein Gene Cause Familial Dilated Cardiomyopathy, Journal of the American College of Cardiology, vol.54, issue.10, pp.930-971, 2009.
DOI : 10.1016/j.jacc.2009.05.038

F. Cambien, O. Poirier, and V. Nicaud, Sequence Diversity in 36 Candidate Genes for Cardiovascular Disorders, The American Journal of Human Genetics, vol.65, issue.1, pp.183-91, 1999.
DOI : 10.1086/302448

T. Cappola, S. Matkovich, and W. Wang, Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation, Proceedings of the National Academy of Sciences, vol.108, issue.6, pp.2456-61, 2011.
DOI : 10.1073/pnas.1017494108

S. Carballo, P. Robinson, and R. Otway, Identification and Functional Characterization of Cardiac Troponin I As a Novel Disease Gene in Autosomal Dominant Dilated Cardiomyopathy, Circulation Research, vol.105, issue.4, pp.375-82, 2009.
DOI : 10.1161/CIRCRESAHA.109.196055

E. Carniel, M. Taylor, and G. Sinagra, ??-Myosin Heavy Chain: A Sarcomeric Gene Associated With Dilated and Hypertrophic Phenotypes of Cardiomyopathy, Circulation, vol.112, issue.1, pp.54-63, 2005.
DOI : 10.1161/CIRCULATIONAHA.104.507699

P. Charron and M. Komajda, Are we ready for pharmacogenomics in heart failure?, European Journal of Pharmacology, vol.417, issue.1-2, pp.1-9, 2001.
DOI : 10.1016/S0014-2999(01)00878-0

P. Charron and M. Komajda, Genes and their polymorphisms in mono- and multifactorial cardiomyopathies:, Pharmacogenomics, vol.3, issue.3, pp.367-78, 2002.
DOI : 10.1517/14622416.3.3.367

P. Charron, F. Tesson, and O. Poirier, Identification of a genetic risk factor for idiopathic dilated cardiomyopathy. Involvement of a polymorphism in the endothelin receptor type A gene, European Heart Journal, vol.20, issue.21, pp.1587-91, 1999.
DOI : 10.1053/euhj.1999.1696

Z. Chen, Q. Qian, and G. Ma, A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease, Molecular Biology Reports, vol.24, issue.Suppl 1, pp.889-93, 2009.
DOI : 10.1007/s11033-008-9259-7

M. Codd, D. Sugrue, B. Gersh, and L. Melton, Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984, Circulation, vol.80, issue.3, pp.564-72, 1975.
DOI : 10.1161/01.CIR.80.3.564

M. Comabella, D. Craig, and M. Camina-tato, Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-Wide Scan of 500,000 Single Nucleotide Polymorphisms, PLoS ONE, vol.28, issue.10, p.3490, 2008.
DOI : 10.1371/journal.pone.0003490.s002

C. Combadiere, O. Godin, C. Vidal, A. Cangialosi, C. Proust et al., Common CX3CR1 Alleles Are Associated With a Reduced Risk of Headaches, Headache: The Journal of Head and Face Pain, vol.103, issue.7, pp.1061-1067, 2008.
DOI : 10.1111/j.1526-4610.2007.01011.x

URL : https://hal.archives-ouvertes.fr/inserm-00175880

D. Conrad, M. Jakobsson, and G. Coop, A worldwide survey of haplotype variation and linkage disequilibrium in the human genome, Nature Genetics, vol.155, issue.11, pp.1251-60, 2006.
DOI : 10.1038/ng1911

. Consortium and . Ih, A haplotype map of the human genome, Nature, vol.437, issue.7063, pp.1299-320, 2005.
DOI : 10.1038/nature04226

S. Daehmlow, J. Erdmann, and T. Knueppel, Novel mutations in sarcomeric protein genes in dilated cardiomyopathy, Biochemical and Biophysical Research Communications, vol.298, issue.1, pp.116-136, 2002.
DOI : 10.1016/S0006-291X(02)02374-4

G. Dec and V. Fuster, Idiopathic Dilated Cardiomyopathy, New England Journal of Medicine, vol.331, issue.23, pp.1564-75, 1994.
DOI : 10.1056/NEJM199412083312307

P. Doran, J. Gannon, O. Connell, K. Ohlendieck, and K. , Aging skeletal muscle shows a drastic increase in the small heat shock proteins ??B-crystallin/HspB5 and cvHsp/HspB7, European Journal of Cell Biology, vol.86, issue.10, pp.629-669, 2007.
DOI : 10.1016/j.ejcb.2007.07.003

L. Duboscq-bidot, P. Charron, and V. Ruppert, Mutations in the ANKRD1 gene encoding CARP are responsible for human dilated cardiomyopathy, European Heart Journal, vol.30, issue.17, pp.2128-2164, 2009.
DOI : 10.1093/eurheartj/ehp225

L. Duboscq-bidot, P. Xu, and P. Charron, Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy, Cardiovascular Research, vol.77, issue.1, pp.118-143, 2008.
DOI : 10.1093/cvr/cvm015

P. Elliott, B. Andersson, and E. Arbustini, Classification of the cardiomyopathies: a position statement from the european society of cardiology working group on myocardial and pericardial diseases, European Heart Journal, vol.29, issue.2, pp.270-276, 2008.
DOI : 10.1093/eurheartj/ehm342

A. Evans, V. Salomaa, and S. Kulathinal, MORGAM (an international pooling of cardiovascular cohorts), International Journal of Epidemiology, vol.34, issue.1, pp.21-28, 2005.
DOI : 10.1093/ije/dyh327

M. Everly, Cardiac transplantation in the United States: an analysis of the UNOS registry, Clin Transpl, pp.35-43, 2008.

D. Fatkin, C. Macrae, and T. Sasaki, Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease, New England Journal of Medicine, vol.341, issue.23, pp.1715-1739, 1999.
DOI : 10.1056/NEJM199912023412302

N. Ferreira-maldent, F. Maillot, L. Quilliet, J. Guilmot, and B. Charbonnier, Dilated cardiomyopathy, diabetes and deafness related to a mutation of mitochondrial DNA], Arch Mal Coeur Vaiss, vol.100, issue.2, pp.149-52, 2007.

P. Franks, Identifying genes for primary hypertension: methodological limitations and gene???environment interactions, Journal of Human Hypertension, vol.146, issue.4, pp.227-264, 2009.
DOI : 10.1161/CIRCULATIONAHA.107.185649

S. Gabriel, S. Schaffner, and H. Nguyen, The Structure of Haplotype Blocks in the Human Genome, Science, vol.296, issue.5576, pp.2225-2234, 2002.
DOI : 10.1126/science.1069424

M. Gamerdinger, P. Hajieva, A. Kaya, U. Wolfrum, F. Hartl et al., Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3, The EMBO Journal, vol.3, issue.7, pp.889-901, 2009.
DOI : 10.1038/nrm1492

C. Geier, A. Perrot, and C. Ozcelik, Mutations in the Human Muscle LIM Protein Gene in Families With Hypertrophic Cardiomyopathy, Circulation, vol.107, issue.10, pp.1390-1395, 2003.
DOI : 10.1161/01.CIR.0000056522.82563.5F

B. Gerull, M. Gramlich, and J. Atherton, Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy, Nature Genetics, vol.30, issue.2, pp.201-205, 2002.
DOI : 10.1038/ng815

J. Goerss, V. Michels, and J. Burnett, Frequency of familial dilated cardiomyopathy, European Heart Journal, vol.16, issue.suppl O, pp.2-4, 1995.
DOI : 10.1093/eurheartj/16.suppl_O.2

U. Goldbourt and H. Neufeld, Genetic aspects of arteriosclerosis, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.6, issue.4, pp.357-77, 1986.
DOI : 10.1161/01.ATV.6.4.357

M. Grisoni, C. Proust, and M. Alanne, Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project, BMC Medical Genetics, vol.13, issue.1, p.44, 2009.
DOI : 10.1007/s00109-007-0234-x

E. Grunig, J. Tasman, H. Kucherer, W. Franz, W. Kubler et al., Frequency and Phenotypes of Familial Dilated Cardiomyopathy, Journal of the American College of Cardiology, vol.31, issue.1, pp.186-94, 1998.
DOI : 10.1016/S0735-1097(97)00434-8

K. Gunderson, F. Steemers, and H. Ren, Whole???Genome Genotyping, Methods Enzymol, vol.410, pp.359-76, 2006.
DOI : 10.1016/S0076-6879(06)10017-8

D. Hassel, T. Dahme, and J. Erdmann, Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy, Nature Medicine, vol.21, issue.11, pp.1281-1289, 2009.
DOI : 10.1038/nm.2037

T. Hayashi, T. Arimura, and K. Ueda, Identification and functional analysis of a caveolin-3 mutation associated with familial hypertrophic cardiomyopathy, Biochemical and Biophysical Research Communications, vol.313, issue.1, pp.178-84, 2004.
DOI : 10.1016/j.bbrc.2003.11.101

A. Helgadottir, G. Thorleifsson, and K. Magnusson, The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm, Nature Genetics, vol.56, issue.2, pp.217-241, 2008.
DOI : 10.1038/ng.72

D. Herman, L. Lam, and M. Taylor, Truncations of Titin Causing Dilated Cardiomyopathy, New England Journal of Medicine, vol.366, issue.7, pp.619-647, 2012.
DOI : 10.1056/NEJMoa1110186

S. Herrmann, K. Schmidt-petersen, and J. Pfeifer, A polymorphism in the endothelin-A receptor gene predicts survival in patients with idiopathic dilated cardiomyopathy, European Heart Journal, vol.22, issue.20, pp.1948-53, 2001.
DOI : 10.1053/euhj.2001.2626

R. Hershberger, J. Kushner, and S. Parks, Dilated Cardiomyopathy Overview, 1993.

R. Hershberger, J. Kushner, and S. Parks, Dilated Cardiomyopathy Overview, 2007.

R. Hershberger, N. Norton, A. Morales, D. Li, J. Siegfried et al., Coding Sequence Rare Variants Identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 From 312 Patients With Familial or Idiopathic Dilated Cardiomyopathy, Circulation: Cardiovascular Genetics, vol.3, issue.2, pp.155-61, 2010.
DOI : 10.1161/CIRCGENETICS.109.912345

R. Hershberger and J. Siegfried, Update 2011: Clinical and Genetic Issues in Familial Dilated Cardiomyopathy, Journal of the American College of Cardiology, vol.57, issue.16, pp.1641-1650, 2011.
DOI : 10.1016/j.jacc.2011.01.015

S. Hiroi, H. Harada, H. Nishi, M. Satoh, R. Nagai et al., Polymorphisms in the SOD2 and HLA-DRB1 Genes Are Associated with Nonfamilial Idiopathic Dilated Cardiomyopathy in Japanese, Biochemical and Biophysical Research Communications, vol.261, issue.2, pp.332-341, 1999.
DOI : 10.1006/bbrc.1999.1036

J. Hirschhorn and M. Daly, Genome-wide association studies for common diseases and complex traits, Nature Reviews Genetics, vol.158, issue.2, pp.95-108, 2005.
DOI : 10.1086/339258

B. Hoffmann, H. Schmidt-traub, A. Perrot, K. Osterziel, and R. Gessner, First mutation in cardiac troponin C, L29Q, in a patient with hypertrophic cardiomyopathy, Human Mutation, vol.17, issue.6, p.524, 2001.
DOI : 10.1002/humu.1143

M. Holden, R. Haynes, S. Rabb, N. Satija, K. Yang et al., Factors Affecting Quantification of Total DNA by UV Spectroscopy and PicoGreen Fluorescence, Journal of Agricultural and Food Chemistry, vol.57, issue.16, pp.7221-7227, 2009.
DOI : 10.1021/jf901165h

C. Holweg, C. Baan, and H. Niesters, TGF-??1 Gene polymorphisms in patients with end-stage heart failure, The Journal of Heart and Lung Transplantation, vol.20, issue.9, pp.979-84, 2001.
DOI : 10.1016/S1053-2498(01)00296-0

S. Homma, M. Iwasaki, G. Shelton, E. Engvall, J. Reed et al., BAG3 Deficiency Results in Fulminant Myopathy and Early Lethality, The American Journal of Pathology, vol.169, issue.3, pp.761-73, 2006.
DOI : 10.2353/ajpath.2006.060250

S. Ichihara, Y. Yamada, and M. Yokota, Association of a G994->T Missense Mutation in the Plasma Platelet-Activating Factor Acetylhydrolase Gene With Genetic Susceptibility to Nonfamilial Dilated Cardiomyopathy in Japanese, Circulation, vol.98, issue.18, pp.1881-1886, 1998.
DOI : 10.1161/01.CIR.98.18.1881

N. Inagaki, T. Hayashi, and T. Arimura, ??B-crystallin mutation in dilated cardiomyopathy, Biochemical and Biophysical Research Communications, vol.342, issue.2, pp.379-86, 2006.
DOI : 10.1016/j.bbrc.2006.01.154

S. Jee, I. Suh, S. Won, and M. Kim, Familial Correlation and Heritability for Cardiovascular Risk Factors, Yonsei Medical Journal, vol.43, issue.2, pp.160-164, 2002.
DOI : 10.3349/ymj.2002.43.2.160

J. Jefferies and J. Towbin, Dilated cardiomyopathy, The Lancet, vol.375, issue.9716, pp.752-62, 2010.
DOI : 10.1016/S0140-6736(09)62023-7

M. Jung, I. Poepping, and A. Perrot, Investigation of a Family with Autosomal Dominant Dilated Cardiomyopathy Defines a Novel Locus on Chromosome 2q14-q22, The American Journal of Human Genetics, vol.65, issue.4, pp.1068-77, 1999.
DOI : 10.1086/302580

M. Kamisago, S. Sharma, and S. Depalma, Mutations in Sarcomere Protein Genes as a Cause of Dilated Cardiomyopathy, New England Journal of Medicine, vol.343, issue.23, pp.1688-96, 2000.
DOI : 10.1056/NEJM200012073432304

A. Kimura, Contribution of Genetic Factors to the Pathogenesis of Dilated Cardiomyopathy, Circulation Journal, vol.75, issue.7, pp.1756-65, 2011.
DOI : 10.1253/circj.CJ-11-0368

A. Kimura, H. Harada, and J. Park, Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy, Nature Genetics, vol.91, issue.4, pp.379-82, 1997.
DOI : 10.1083/jcb.114.5.941

G. Kirov, I. Nikolov, L. Georgieva, V. Moskvina, M. Owen et al., Pooled DNA genotyping on Affymetrix SNP genotyping arrays, BMC Genomics, vol.7, issue.1, p.27, 2006.
DOI : 10.1186/1471-2164-7-27

R. Knoll, M. Hoshijima, and H. Hoffman, The Cardiac Mechanical Stretch Sensor Machinery Involves a Z Disc Complex that Is Defective in a Subset of Human Dilated Cardiomyopathy, Cell, vol.111, issue.7, pp.943-55, 2002.
DOI : 10.1016/S0092-8674(02)01226-6

R. Knoll, R. Postel, and J. Wang, Laminin-??4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells, Circulation, vol.116, issue.5, pp.515-540, 2007.
DOI : 10.1161/CIRCULATIONAHA.107.689984

M. Knuiman, M. Divitini, T. Welborn, and H. Bartholomew, Familial correlations, cohabitation effects, and heritability for cardiovascular risk factors, Annals of Epidemiology, vol.6, issue.3, pp.188-94, 1996.
DOI : 10.1016/1047-2797(96)00004-X

M. Krajinovic, B. Pinamonti, and G. Sinagra, Linkage of familial dilated cardiomyopathy to chromosome 9. Heart Muscle Disease Study Group, Am J Hum Genet, vol.57, issue.4, pp.846-52, 1995.

S. Krief, J. Faivre, and P. Robert, Identification and Characterization of cvHsp: A NOVEL HUMAN SMALL STRESS PROTEIN SELECTIVELY EXPRESSED IN CARDIOVASCULAR AND INSULIN-SENSITIVE TISSUES, Journal of Biological Chemistry, vol.274, issue.51, pp.36592-600, 1999.
DOI : 10.1074/jbc.274.51.36592

L. Kruglyak, Power tools for human genetics, Nature Genetics, vol.309, issue.12, pp.1299-300, 2005.
DOI : 10.1038/ng1205-1299

E. Lander, L. Linton, and B. Birren, Initial sequencing and analysis of the human genome, Nature, vol.6, issue.6822, pp.860-921, 2001.
DOI : 10.1038/35057062

A. Landstrom, N. Weisleder, and K. Batalden, Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans, Journal of Molecular and Cellular Cardiology, vol.42, issue.6, pp.1026-1061, 2007.
DOI : 10.1016/j.yjmcc.2007.04.006

J. Lee, M. Choi, X. Yan, R. Lifton, and H. Zhao, On optimal pooling designs to identify rare variants through massive resequencing, Genetic Epidemiology, vol.173, issue.3, pp.139-186, 2011.
DOI : 10.1002/gepi.20561

A. Levitas, E. Muhammad, and G. Harel, Familial neonatal isolated cardiomyopathy caused by a mutation in the flavoprotein subunit of succinate dehydrogenase, European Journal of Human Genetics, vol.93, issue.10, pp.1160-1165, 2010.
DOI : 10.1007/BF00711676

D. Li, S. Parks, and J. Kushner, Mutations of Presenilin Genes in Dilated Cardiomyopathy and Heart Failure, The American Journal of Human Genetics, vol.79, issue.6, pp.1030-1039, 2006.
DOI : 10.1086/509900

D. Li, T. Tapscoft, and O. Gonzalez, Desmin Mutation Responsible for Idiopathic Dilated Cardiomyopathy, Circulation, vol.100, issue.5, pp.461-465, 1999.
DOI : 10.1161/01.CIR.100.5.461

S. Liggett, L. Wagoner, and L. Craft, The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure., Journal of Clinical Investigation, vol.102, issue.8, pp.1534-1543, 1998.
DOI : 10.1172/JCI4059

S. Lindquist and E. Craig, The Heat-Shock Proteins, Annual Review of Genetics, vol.22, issue.1, pp.631-77, 1988.
DOI : 10.1146/annurev.ge.22.120188.003215

Q. Liu, T. Drgon, and D. Walther, Pooled association genome scanning: Validation and use to identify addiction vulnerability loci in two samples, Proceedings of the National Academy of Sciences, vol.102, issue.33, pp.11864-11873, 2005.
DOI : 10.1073/pnas.0500329102

E. Loh, T. Rebbeck, P. Mahoney, D. Denofrio, J. Swain et al., Common Variant in AMPD1 Gene Predicts Improved Clinical Outcome in Patients With Heart Failure, Circulation, vol.99, issue.11, pp.1422-1427, 1999.
DOI : 10.1161/01.CIR.99.11.1422

S. Macgregor, Z. Zhao, A. Henders, M. Nicholas, G. Montgomery et al., Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arrays, Nucleic Acids Research, vol.36, issue.6, p.35, 2008.
DOI : 10.1093/nar/gkm1060

URL : http://doi.org/10.1093/nar/gkm1060

L. Mangin, P. Charron, and F. Tesson, Familial dilated cardiomyopathy: clinical features in French families, European Journal of Heart Failure, vol.72, issue.5, pp.353-61, 1999.
DOI : 10.1016/S1388-9842(99)00047-1

URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.588.551

B. Maron, J. Towbin, and G. Thiene, Contemporary Definitions and Classification of the Cardiomyopathies: An American Heart Association Scientific Statement From the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention, Circulation, vol.113, issue.14, pp.1807-1823, 2006.
DOI : 10.1161/CIRCULATIONAHA.106.174287

S. Matkovich, D. Van-booven, and A. Hindes, Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease, Journal of Clinical Investigation, vol.120, issue.1, pp.280-289, 2010.
DOI : 10.1172/JCI39085DS1

H. Matsuzaki, H. Loi, and S. Dong, Parallel Genotyping of Over 10,000 SNPs Using a One-Primer Assay on a High-Density Oligonucleotide Array, Genome Research, vol.14, issue.3, pp.414-439, 2004.
DOI : 10.1101/gr.2014904

W. Mcnair, L. Ku, and M. Taylor, SCN5A Mutation Associated With Dilated Cardiomyopathy, Conduction Disorder, and Arrhythmia, Circulation, vol.110, issue.15, pp.2163-2170, 2004.
DOI : 10.1161/01.CIR.0000144458.58660.BB

D. Mcnamara, R. Holubkov, and L. Postava, Effect of the Asp298 Variant of Endothelial Nitric Oxide Synthase on Survival for Patients With Congestive Heart Failure, Circulation, vol.107, issue.12, pp.1598-602, 2003.
DOI : 10.1161/01.CIR.0000060540.93836.AA

E. Meaburn, L. Butcher, and L. Liu, Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs, BMC Genomics, vol.6, issue.1, p.52, 2005.
DOI : 10.1186/1471-2164-6-52

D. Messina, M. Speer, M. Pericak-vance, and E. Mcnally, Linkage of Familial Dilated Cardiomyopathy with Conduction Defect and Muscular Dystrophy to Chromosome 6q23, The American Journal of Human Genetics, vol.61, issue.4, pp.909-926, 1997.
DOI : 10.1086/514896

L. Mestroni, B. Maisch, and W. Mckenna, Guidelines for the study of familial dilated cardiomyopathies, European Heart Journal, vol.20, issue.2, pp.93-102, 1999.
DOI : 10.1053/euhj.1998.1145

S. Miller, D. Dykes, and H. Polesky, A simple salting out procedure for extracting DNA from human nucleated cells, Nucleic Acids Research, vol.16, issue.3, p.1215, 1988.
DOI : 10.1093/nar/16.3.1215

F. Mizon-gerard, P. De-groote, and N. Lamblin, Prognostic impact of matrix metalloproteinase gene polymorphisms in patients with heart failure according to the aetiology of left ventricular systolic dysfunction, European Heart Journal, vol.25, issue.8, pp.688-93, 2004.
DOI : 10.1016/j.ehj.2004.01.015

J. Mogensen, R. Murphy, and T. Shaw, Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy, Journal of the American College of Cardiology, vol.44, issue.10, pp.2033-2073, 2004.
DOI : 10.1016/j.jacc.2004.08.027

B. Mohapatra, S. Jimenez, and J. Lin, Mutations in the muscle LIM protein and ??-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis, Molecular Genetics and Metabolism, vol.80, issue.1-2, pp.207-222, 2003.
DOI : 10.1016/S1096-7192(03)00142-2

M. Moulik, M. Vatta, and S. Witt, ANKRD1, the Gene Encoding Cardiac Ankyrin Repeat Protein, Is a Novel Dilated Cardiomyopathy Gene, Journal of the American College of Cardiology, vol.54, issue.4, pp.325-358, 2009.
DOI : 10.1016/j.jacc.2009.02.076

M. Mullen, C. Creevey, and D. Berry, Polymorphism discovery and allele frequency estimation using high-throughput DNA sequencing of target-enriched pooled DNA samples, BMC Genomics, vol.13, issue.1, p.16, 2012.
DOI : 10.1101/gr.100040.109

R. Murphy, J. Mogensen, A. Shaw, T. Kubo, S. Hughes et al., Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy, The Lancet, vol.363, issue.9406, pp.371-373, 2004.
DOI : 10.1016/S0140-6736(04)15468-8

C. Murray and A. Lopez, Alternative projections of mortality and disability by cause 1990???2020: Global Burden of Disease Study, The Lancet, vol.349, issue.9064, pp.1498-504, 1997.
DOI : 10.1016/S0140-6736(96)07492-2

J. Neaton, H. Blackburn, and D. Jacobs, Serum cholesterol level and mortality findings for men screened in the Multiple Risk Factor Intervention Trial. Multiple Risk Factor Intervention Trial Research Group, Archives of Internal Medicine, vol.152, issue.7, pp.1490-500, 1992.
DOI : 10.1001/archinte.152.7.1490

V. Nicaud, C. Francomme, and J. Ruidavets, Lack of association between complement factor H polymorphisms and coronary artery disease or myocardial infarction, Journal of Molecular Medicine, vol.38, issue.7, pp.771-776, 2007.
DOI : 10.1007/s00109-007-0185-2

H. Niimura, K. Patton, and W. Mckenna, Sarcomere Protein Gene Mutations in Hypertrophic Cardiomyopathy of the Elderly, Circulation, vol.105, issue.4, pp.446-51, 2002.
DOI : 10.1161/hc0402.102990

T. Olson, S. Illenberger, N. Kishimoto, S. Huttelmaier, M. Keating et al., Metavinculin Mutations Alter Actin Interaction in Dilated Cardiomyopathy, Circulation, vol.105, issue.4, pp.431-438, 2002.
DOI : 10.1161/hc0402.102930

T. Olson, N. Kishimoto, F. Whitby, and V. Michels, Mutations that Alter the Surface Charge of Alpha-tropomyosin are Associated with Dilated Cardiomyopathy, Journal of Molecular and Cellular Cardiology, vol.33, issue.4, pp.723-755, 2001.
DOI : 10.1006/jmcc.2000.1339

T. Olson, V. Michels, S. Thibodeau, Y. Tai, and M. Keating, Actin Mutations in Dilated Cardiomyopathy, a Heritable Form of Heart Failure, Science, vol.280, issue.5364, pp.750-752, 1998.
DOI : 10.1126/science.280.5364.750

A. Osio, L. Tan, and S. Chen, Myozenin 2 Is a Novel Gene for Human Hypertrophic Cardiomyopathy, Circulation Research, vol.100, issue.6, pp.766-774, 2007.
DOI : 10.1161/01.RES.0000263008.66799.aa

A. Out, I. Van-minderhout, and J. Goeman, Deep sequencing to reveal new variants in pooled DNA samples, Human Mutation, vol.124, issue.12, pp.1703-1715, 2009.
DOI : 10.1002/humu.21122

J. Pearson, M. Huentelman, and R. Halperin, Identification of the Genetic Basis for Complex Disorders by Use of Pooling-Based Genomewide Single-Nucleotide???Polymorphism Association Studies, The American Journal of Human Genetics, vol.80, issue.1, pp.126-165, 2007.
DOI : 10.1086/510686

K. Poetter, H. Jiang, and S. Hassanzadeh, Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle, Nature Genetics, vol.24, issue.1, pp.63-72, 1996.
DOI : 10.1038/ng0596-63

P. Richardson, W. Mckenna, and M. Bristow, Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies, Circulation, vol.93, issue.5, pp.841-843, 1996.

V. Roger, A. Go, and D. Lloyd-jones, Heart Disease and Stroke Statistics--2011 Update: A Report From the American Heart Association, Circulation, vol.123, issue.4, pp.18-209, 2011.
DOI : 10.1161/CIR.0b013e3182009701

J. Schmitt, M. Kamisago, and M. Asahi, Dilated Cardiomyopathy and Heart Failure Caused by a Mutation in Phospholamban, Science, vol.299, issue.5611, pp.1410-1413, 2003.
DOI : 10.1126/science.1081578

J. Schonberger, L. Kuhler, E. Martins, T. Lindner, J. Silva-cardoso et al., A novel locus for autosomal-dominant dilated cardiomyopathy maps to chromosome 7q22.3-31, Hum Genet, vol.1118, pp.3-4451, 2005.

J. Schonberger, H. Levy, and E. Grunig, Dilated Cardiomyopathy and Sensorineural Hearing Loss : A Heritable Syndrome That Maps to 6q23-24, Circulation, vol.101, issue.15, pp.1812-1820, 2000.
DOI : 10.1161/01.CIR.101.15.1812

J. Schonberger and C. Seidman, Many Roads Lead to a Broken Heart: The Genetics of Dilated Cardiomyopathy, The American Journal of Human Genetics, vol.69, issue.2, pp.249-60, 2001.
DOI : 10.1086/321978

J. Schonberger, L. Wang, and J. Shin, Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss, Nature Genetics, vol.203, issue.4, pp.418-440, 2005.
DOI : 10.1128/MCB.23.17.5989-5999.2003

I. Schrauwen, M. Ealy, and M. Huentelman, A Genome-wide Analysis Identifies Genetic Variants in the RELN Gene Associated with Otosclerosis, The American Journal of Human Genetics, vol.84, issue.3, pp.328-366, 2009.
DOI : 10.1016/j.ajhg.2009.01.023

H. Schunkert, I. Konig, and S. Kathiresan, Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease, Nature Genetics, vol.6, issue.4, pp.333-341, 2011.
DOI : 10.1038/ng.291

J. Seidman and C. Seidman, The Genetic Basis for Cardiomyopathy, Cell, vol.104, issue.4, pp.557-67, 2001.
DOI : 10.1016/S0092-8674(01)00242-2

P. Sham, J. Bader, I. Craig, O. Donovan, M. Owen et al., DNA Pooling: a tool for large-scale association studies, Nature Reviews Genetics, vol.29, issue.11, pp.862-71, 2002.
DOI : 10.1038/nrg930

T. Shaw, P. Elliott, and W. Mckenna, Dilated cardiomyopathy: a genetically heterogeneous disease, The Lancet, vol.360, issue.9334, pp.654-659, 2002.
DOI : 10.1016/S0140-6736(02)09879-3

J. Shea, V. Agarwala, and A. Philippakis, Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction, Nature Genetics, vol.79, issue.8, pp.801-805, 2011.
DOI : 10.1086/519795

S. Sile, D. Velez, N. Gillani, C. Alexander, A. George et al., Haplotype Diversity in Four Genes <i>(CLCNKA, CLCNKB, BSND, NEDD4L) </i>Involved in Renal Salt Reabsorption, Human Heredity, vol.65, issue.1, pp.33-46, 2008.
DOI : 10.1159/000106060

V. Singer, L. Jones, S. Yue, and R. Haugland, Characterization of PicoGreen Reagent and Development of a Fluorescence-Based Solution Assay for Double-Stranded DNA Quantitation, Analytical Biochemistry, vol.249, issue.2, pp.228-266, 1997.
DOI : 10.1006/abio.1997.2177

C. Skibola, P. Bracci, and E. Halperin, Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma, Nature Genetics, vol.13, issue.8, pp.873-878, 2009.
DOI : 10.1038/ng.219

N. Smith, J. Felix, and A. Morrison, Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry: A Prospective Meta-Analysis From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Circulation: Cardiovascular Genetics, vol.3, issue.3, pp.256-66, 2010.
DOI : 10.1161/CIRCGENETICS.109.895763

K. Stark, U. Esslinger, and W. Reinhard, Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy, PLoS Genetics, vol.105, issue.10, p.1001167, 2010.
DOI : 10.1371/journal.pgen.1001167.s003

H. Stary, A. Chandler, and R. Dinsmore, A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis : A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.15, issue.9, pp.1512-1543, 1995.
DOI : 10.1161/01.ATV.15.9.1512

F. Steemers and K. Gunderson, Whole genome genotyping technologies on the BeadArray??? platform, Biotechnology Journal, vol.314, issue.1, pp.41-50, 2007.
DOI : 10.1002/biot.200600213

N. Sylvius, F. Tesson, and C. Gayet, A New Locus for Autosomal Dominant Dilated Cardiomyopathy Identified on Chromosome 6q12-q16, The American Journal of Human Genetics, vol.68, issue.1, pp.241-247, 2001.
DOI : 10.1086/316929

M. Taylor, D. Slavov, and A. Gajewski, Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy, Human Mutation, vol.117, issue.6, pp.566-74, 2005.
DOI : 10.1002/humu.20250

G. Thiene, D. Corrado, and C. Basso, Cardiomyopathies: is it time for a molecular classification?, European Heart Journal, vol.25, issue.20, pp.1772-1777, 2004.
DOI : 10.1016/j.ehj.2004.07.026

D. Thomas, R. Haile, and D. Duggan, Recent Developments in Genomewide Association Scans: A Workshop Summary and Review, The American Journal of Human Genetics, vol.77, issue.3, pp.337-382, 2005.
DOI : 10.1086/432962

L. Tiret, C. Mallet, and O. Poirier, Lack of association between polymorphisms of eight candidate genes and idiopathic dilated cardiomyopathy, Journal of the American College of Cardiology, vol.35, issue.1, pp.29-35, 2000.
DOI : 10.1016/S0735-1097(99)00522-7

L. Tiret, O. Poirier, and V. Nicaud, Heterogeneity of linkage disequilibrium in human genes has implications for association studies of common diseases, Human Molecular Genetics, vol.11, issue.4, pp.419-448, 2002.
DOI : 10.1093/hmg/11.4.419

J. Towbin and N. Bowles, Genetic abnormalities responsible for dilated cardiomyopathy, Current Cardiology Reports, vol.330, issue.5, pp.475-80, 2000.
DOI : 10.1007/s11886-000-0063-9

J. Towbin and N. Bowles, Sarcoglycan, the heart, and skeletal muscles: new treatment, old drug?, Journal of Clinical Investigation, vol.107, issue.2, pp.153-157, 2001.
DOI : 10.1172/JCI11998

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC199185

J. Towbin, J. Hejtmancik, and P. Brink, X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus, Circulation, vol.87, issue.6, pp.1854-65, 1993.
DOI : 10.1161/01.CIR.87.6.1854

D. Tregouet, S. Escolano, L. Tiret, A. Mallet, and J. Golmard, A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm, Annals of Human Genetics, vol.85, issue.2, pp.165-77, 2004.
DOI : 10.1159/000048602

D. Tregouet and V. Garelle, A new JAVA interface implementation of THESIAS: testing haplotype effects in association studies, Bioinformatics, vol.23, issue.8, pp.1038-1047, 2007.
DOI : 10.1093/bioinformatics/btm058

S. Tsubata, K. Bowles, and M. Vatta, Mutations in the human ??-sarcoglycan gene in familial and sporadic dilated cardiomyopathy, Journal of Clinical Investigation, vol.106, issue.5, pp.655-62, 2000.
DOI : 10.1172/JCI9224

V. Vasile, W. Edwards, S. Ommen, and M. Ackerman, Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated disc, Biochemical and Biophysical Research Communications, vol.349, issue.2, pp.709-724, 2006.
DOI : 10.1016/j.bbrc.2006.08.106

M. Vatta, B. Mohapatra, and S. Jimenez, Mutations in Cypher/ZASPin patients with dilated cardiomyopathy and left ventricular non-compaction, Journal of the American College of Cardiology, vol.42, issue.11, pp.2014-2041, 2003.
DOI : 10.1016/j.jacc.2003.10.021

J. Venter, M. Adams, and E. Myers, The Sequence of the Human Genome, Science, vol.291, issue.5507, pp.1304-51, 2001.
DOI : 10.1126/science.1058040

URL : https://hal.archives-ouvertes.fr/hal-00465088

S. Vesel, M. Stopar-obreza, K. Trebusak-podkrajsek, J. Jazbec, T. Podnar et al., A novel mutation in the G4.5 (TAZ) gene in a kindred with Barth syndrome, European Journal of Human Genetics, vol.11, issue.1, pp.97-101, 2003.
DOI : 10.1038/sj.ejhg.5200926

E. Villard, C. Perret, and F. Gary, A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy, European Heart Journal, vol.32, issue.9, pp.1065-76
DOI : 10.1093/eurheartj/ehr105

URL : https://hal.archives-ouvertes.fr/hal-00616568

T. Wang, K. Pradhan, K. Ye, L. Wong, and T. Rohan, Estimating allele frequency from nextgeneration sequencing of pooled mitochondrial DNA samples, Front Genet, vol.2, p.51, 2011.

H. Watkins, D. Conner, and L. Thierfelder, Mutations in the cardiac myosin binding protein???C gene on chromosome 11 cause familial hypertrophic cardiomyopathy, Nature Genetics, vol.216, issue.4, pp.434-441, 1995.
DOI : 10.1016/0304-4165(80)90071-9

D. Wencker, M. Chandra, and K. Nguyen, A mechanistic role for cardiac myocyte apoptosis in heart failure, Journal of Clinical Investigation, vol.111, issue.10, pp.1497-504, 2003.
DOI : 10.1172/JCI17664

K. Yasuno, K. Bilguvar, and P. Bijlenga, Genome-wide association study of intracranial aneurysm identifies three new risk loci, Nature Genetics, vol.130, issue.5, pp.420-425, 2010.
DOI : 10.1371/journal.pgen.1000540

I. Zak, P. Niemiec, A. Balcerzyk, and J. Krauze, genes increase the risk of the coronary artery disease associated with the presence of cigarette smoking, Acta Cardiologica, vol.63, issue.6, pp.741-748, 2008.
DOI : 10.2143/AC.63.6.2033392

E. Zeggini, W. Rayner, and A. Morris, An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets, Nature Genetics, vol.429, issue.12, pp.1320-1322, 2005.
DOI : 10.1038/ng1670

D. Zhang, J. Mott, and P. Farrar, Mitochondrial DNA mutations activate the mitochondrial apoptotic pathway and cause dilated cardiomyopathy, Cardiovascular Research, vol.57, issue.1, pp.147-57, 2003.
DOI : 10.1016/S0008-6363(02)00695-8

Z. Zhao, D. Nyholt, M. James, R. Mayne, S. Treloar et al., Abstract, Twin Research and Human Genetics, vol.29, issue.04, pp.353-61, 2005.
DOI : 10.1002/humu.10094

URL : https://hal.archives-ouvertes.fr/hal-00218335