Proof-functional logical connectives allow reasoning about the structure of logical proofs, in this way giving to the latter the status of first-class objects. This is in contrast to classical truth-functional connectives where the meaning of a compound formula is dependent only on the truth value of its subformulas. We present a proof-functional logic and we give a semantics using Mints' realizers accounting for intersection types, union types, and subtyping. The semantics interprets the type ω as the set universe, the → type as a function space, the ∩ and ∪ types as set intersection and set union, respectively, and the subtype relation as a subset operator. Using the proof-as-types and terms-as-propositions paradigms, we extend the typed calculus previously defined by the authors with a decidable subtyping relation and we show this calculus to be isomorphic to the Barbanera-Dezani-Ciancaglini-de'Liguoro type assignment system. A subtyping algorithm is presented and proved to be sound and complete. Hindley gave a subtyping algorithm for intersection types but, as far as we know, there is no system in the literature also including union types.