CNRS - Centre National de la Recherche Scientifique : UMR8623, X - École polytechnique, Inria Saclay - Ile de France, UP11 - Université Paris-Sud - Paris 11, LRI - Laboratoire de Recherche en Informatique, LIX - Laboratoire d'informatique de l'École polytechnique [Palaiseau]
3AMIB - Algorithms and Models for Integrative Biology (Algorithmes et modèles pour la Biologie Intégrative
Bâtiment Alan Turing - Campus de l'École Polytechnique - 1 rue Honoré d'Estienne d'Orves - 91120 Palaiseau - France)
Abstract : Pairwise ordered tree alignment are combinatorial objects that appear in important applications , such as RNA secondary structure comparison. However, the usual representation of tree alignments as supertrees is ambiguous, i.e. two distinct supertrees may induce identical sets of matches between identical pairs of trees. This ambiguity is uninformative, and detrimental to any probabilistic analysis. In this work, we consider tree alignments up to equivalence. Our first result is a precise asymptotic enumeration of tree alignments, obtained from a context-free grammar by mean of basic analytic combinatorics. Our second result focuses on alignments between two given ordered trees S and T. By refining our grammar to align specific trees, we obtain a decomposition scheme for the space of alignments, and use it to design an efficient dynamic programming algorithm for sampling alignments under the Gibbs-Boltzmann probability distribution. This generalizes existing tree alignment algorithms, and opens the door for a probabilistic analysis of the space of suboptimal alignments.
https://hal.inria.fr/hal-01500116
Contributeur : Yann Ponty
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Soumis le : dimanche 2 avril 2017 - 12:50:39
Dernière modification le : jeudi 12 avril 2018 - 01:50:33
Document(s) archivé(s) le : lundi 3 juillet 2017 - 13:20:51
Cedric Chauve, Julien Courtiel, Yann Ponty. Counting, generating, analyzing and sampling tree alignments. International Journal of Foundations of Computer Science, World Scientific Publishing, 2018. 〈hal-01500116〉
