J. A. Dani and R. A. Harris, Nicotine addiction and comorbidity with alcohol abuse and mental illness, Nature Neuroscience, vol.26, issue.11, pp.1465-1470, 2005.
DOI : 10.1016/j.addbeh.2004.06.014

L. M. Hendrickson, M. J. Guildford, and A. R. Tapper, Neuronal Nicotinic Acetylcholine Receptors: Common Molecular Substrates of Nicotine and Alcohol Dependence, Frontiers in Psychiatry, vol.4, p.29, 2013.
DOI : 10.3389/fpsyt.2013.00029

D. E. Falk, H. Yi, and S. Hiller-sturmhöfel, An epidemiologic analysis of co-occurring alcohol and tobacco use and disorders: findings from the National Epidemiologic Survey on Alcohol and Related Conditions, Alcohol Res Health, vol.29, pp.162-171, 2006.

J. R. Difranza and M. P. Guerrera, Alcoholism and smoking., Journal of Studies on Alcohol, vol.51, issue.2, pp.130-135, 1990.
DOI : 10.15288/jsa.1990.51.130

J. K. Bobo and C. Husten, Sociocultural influences on smoking and drinking, Alcohol Res Health, vol.24, pp.225-232, 2000.

I. R. Schlaepfer, N. R. Hoft, and M. A. Ehringer, The Genetic Components of Alcohol and Nicotine Co-Addiction: From Genes to Behavior, Current Drug Abuse Reviewse, vol.1, issue.2, pp.124-134, 2008.
DOI : 10.2174/1874473710801020124

W. M. Doyon, A. M. Thomas, A. Ostroumov, Y. Dong, and J. A. Dani, Potential substrates for nicotine and alcohol interactions: A focus on the mesocorticolimbic dopamine system, Biochemical Pharmacology, vol.86, issue.8, pp.1181-1193, 2013.
DOI : 10.1016/j.bcp.2013.07.007

D. Chiara, G. Imperato, and A. , Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats., Proc. Natl. Acad. Sci. USA, pp.5274-5278, 1988.
DOI : 10.1073/pnas.85.14.5274

M. Mameli-engvall, Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors, Neuron, vol.50, issue.6, pp.911-921, 2006.
DOI : 10.1016/j.neuron.2006.05.007
URL : https://hal.archives-ouvertes.fr/pasteur-00176372

G. L. Gessa, F. Muntoni, M. Collu, L. Vargiu, and G. Mereu, Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area, Brain Research, vol.348, issue.1, pp.201-203, 1985.
DOI : 10.1016/0006-8993(85)90381-6

T. Narahashi, G. L. Aistrup, W. Marszalec, and K. Nagata, Neuronal nicotinic acetylcholine receptors: a new target site of ethanol, Neurochemistry International, vol.35, issue.2, pp.131-141, 1999.
DOI : 10.1016/S0197-0186(99)00055-8

A. D. Lê, W. A. Corrigall, J. W. Harding, W. Juzytsch, and T. K. Li, Involvement of Nicotinic Receptors in Alcohol Self-Administration, Alcoholism: Clinical and Experimental Research, vol.39, issue.2, pp.155-163, 2000.
DOI : 10.1016/S0091-3057(98)00226-3

L. Liu, Nicotinic Acetylcholine Receptors Containing the ??4 Subunit Modulate Alcohol Reward, Biological Psychiatry, vol.73, issue.8, pp.738-746, 2013.
DOI : 10.1016/j.biopsych.2012.09.019
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501776

L. Liu, R. Zhao-shea, J. M. Mcintosh, and A. R. Tapper, Nicotinic acetylcholine receptors containing the ??6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons, Biochemical Pharmacology, vol.86, issue.8, pp.1194-1200, 2013.
DOI : 10.1016/j.bcp.2013.06.015

L. M. Hendrickson, R. Zhao-shea, and A. R. Tapper, Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice, Psychopharmacology, vol.26, issue.4, pp.563-572, 2009.
DOI : 10.1007/s00213-009-1488-5

J. P. Changeux and S. J. Edelstein, Allosteric Receptors after 30 Years, Neuron, vol.21, issue.5, pp.959-980, 1998.
DOI : 10.1016/S0896-6273(00)80616-9
URL : http://doi.org/10.1016/s0896-6273(00)80616-9

S. Tolu, Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement, Molecular Psychiatry, vol.160, issue.3, pp.382-393, 2013.
DOI : 10.1016/j.neuron.2011.01.020

M. R. Picciotto, Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine, Nature, vol.391, pp.173-177, 1998.

U. Maskos, Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors, Nature, vol.47, issue.7047, pp.103-107, 2005.
DOI : 10.1038/nature03694
URL : https://hal.archives-ouvertes.fr/pasteur-00162546

S. Frahm, Aversion to Nicotine Is Regulated by the Balanced Activity of ??4 and ??5 Nicotinic Receptor Subunits in the Medial Habenula, Neuron, vol.70, issue.3, pp.522-535, 2011.
DOI : 10.1016/j.neuron.2011.04.013

L. Harrington, Role of ??4* Nicotinic Acetylcholine Receptors in the Habenulo???Interpeduncular Pathway in Nicotine Reinforcement in Mice, Neuropsychopharmacology, vol.19, issue.7, pp.1-13346, 2015.
DOI : 10.1016/j.cub.2013.09.041

L. J. Bierut, Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25, Trends in Pharmacological Sciences, vol.31, issue.1, pp.46-51, 2010.
DOI : 10.1016/j.tips.2009.10.004

R. Sherva, Variation in Nicotinic Acetylcholine Receptor Genes is Associated with Multiple Substance Dependence Phenotypes, Neuropsychopharmacology, vol.65, issue.9, pp.1921-1931, 2010.
DOI : 10.1038/npp.2010.64
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055642

R. Eddine, A concurrent excitation and inhibition of dopaminergic subpopulations in response to nicotine, Scientific Reports, vol.124, issue.1, p.8184, 2015.
DOI : 10.1007/BF02247433
URL : https://hal.archives-ouvertes.fr/hal-01116458

Y. Tizabi, R. L. Copeland, V. A. Louis, and R. E. Taylor, Effects of Combined Systemic Alcohol and Central Nicotine Administration into Ventral Tegmental Area on Dopamine Release in the Nucleus Accumbens, Alcoholism: Clinical and Experimental Research, vol.20, issue.3, pp.394-399, 2002.
DOI : 10.1016/0306-4603(90)90063-4

Y. Tizabi, L. Bai, R. L. Copeland, and R. E. Taylor, Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell, Alcohol and Alcoholism, vol.42, issue.5, pp.413-416, 2007.
DOI : 10.1093/alcalc/agm057

W. A. Truitt, Ethanol and nicotine interaction within the posterior ventral tegmental area in male and female alcohol-preferring rats: evidence of synergy and differential gene activation in the nucleus accumbens shell, Psychopharmacology, vol.324, issue.5, pp.639-649, 2015.
DOI : 10.1007/s00213-014-3702-3

W. M. Doyon, Nicotine Decreases Ethanol-Induced Dopamine Signaling and Increases Self-Administration via Stress Hormones, Neuron, vol.79, issue.3, p.6, 2013.
DOI : 10.1016/j.neuron.2013.06.006
URL : http://doi.org/10.1016/j.neuron.2013.06.006

R. M. Leao, Chronic Nicotine Activates Stress/Reward-Related Brain Regions and Facilitates the Transition to Compulsive Alcohol Drinking, Journal of Neuroscience, vol.35, issue.15, pp.6241-6253, 2015.
DOI : 10.1523/JNEUROSCI.3302-14.2015

B. Buisson and D. Bertrand, Nicotine addiction: the possible role of functional upregulation, Trends in Pharmacological Sciences, vol.23, issue.3, pp.130-136, 2002.
DOI : 10.1016/S0165-6147(00)01979-9

D. Funk, P. W. Marinelli, and A. D. Lê, Biological processes underlying co-use of alcohol and nicotine: neuronal mechanisms, crosstolerance , and genetic factors, Alcohol Res Health, vol.29, pp.186-192, 2006.

A. Clark and H. J. Little, Interactions between low concentrations of ethanol and nicotine on firing rate of ventral tegmental dopamine neurones, Drug and Alcohol Dependence, vol.75, issue.2, pp.199-206, 2004.
DOI : 10.1016/j.drugalcdep.2004.03.001

S. E. Engle, J. M. Mcintosh, and R. M. Drenan, Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via ??6-containing nicotinic receptors, Neuropharmacology, vol.91, pp.13-22, 2015.
DOI : 10.1016/j.neuropharm.2014.11.014
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312744

P. P. Rowell and M. Li, Dose-Response Relationship for Nicotine-Induced Up-Regulation of Rat Brain Nicotinic Receptors, Journal of Neurochemistry, vol.68, issue.5, pp.1982-1989, 1997.
DOI : 10.1046/j.1471-4159.1997.68051982.x

M. J. Marks, 45116 | DOI: 10.1038/srep45116 35 Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment, Neuropharmacology, vol.7, issue.46, pp.1141-1157, 2004.

M. Besson, Long-term effects of chronic nicotine exposure on brain nicotinic receptors, Proc. Natl. Acad. Sci. USA, pp.8155-8160, 2007.
DOI : 10.1038/374065a0
URL : https://hal.archives-ouvertes.fr/hal-00408809

R. Nashmi, Chronic Nicotine Cell Specifically Upregulates Functional ??4* Nicotinic Receptors: Basis for Both Tolerance in Midbrain and Enhanced Long-Term Potentiation in Perforant Path, Journal of Neuroscience, vol.27, issue.31, pp.8202-8218, 2007.
DOI : 10.1523/JNEUROSCI.2199-07.2007

A. Metaxas, Genetic deletion of the adenosine A2A receptor prevents nicotine-induced upregulation of ??7, but not ??4??2* nicotinic acetylcholine receptor binding in the brain, Neuropharmacology, vol.71, pp.228-236, 2013.
DOI : 10.1016/j.neuropharm.2013.03.023

A. P. Govind, P. Vezina, and W. N. Green, Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction, Biochemical Pharmacology, vol.78, issue.7, pp.756-765, 2009.
DOI : 10.1016/j.bcp.2009.06.011

H. Tan, S. F. Bishop, N. M. Lauzon, N. Sun, and S. R. Laviolette, Chronic nicotine exposure switches the functional role of mesolimbic dopamine transmission in the processing of nicotine's rewarding and aversive effects, Neuropharmacology, vol.56, issue.4, pp.741-751, 2009.
DOI : 10.1016/j.neuropharm.2008.12.008

S. Caille, K. Guillem, M. Cador, O. Manzoni, and F. Georges, Voluntary Nicotine Consumption Triggers In Vivo Potentiation of Cortical Excitatory Drives to Midbrain Dopaminergic Neurons, Journal of Neuroscience, vol.29, issue.33, pp.10410-10415, 2009.
DOI : 10.1523/JNEUROSCI.2950-09.2009
URL : https://hal.archives-ouvertes.fr/hal-01153593

T. E. Grieder, Dopaminergic Signaling Mediates the Motivational Response Underlying the Opponent Process to Chronic but Not Acute Nicotine, Neuropsychopharmacology, vol.292, issue.4, pp.943-954, 2010.
DOI : 10.1016/0091-3057(88)90086-X

O. Blomqvist, M. Ericson, D. H. Johnson, J. A. Engel, and B. Soderpalm, Voluntary ethanol intake in the rat: effects of nicotinic acetylcholine receptor blockade or subchronic nicotine treatment, European Journal of Pharmacology, vol.314, issue.3, pp.257-267, 1996.
DOI : 10.1016/S0014-2999(96)00583-3

Z. Ding, Repeated exposure of the posterior ventral tegmental area to nicotine increases the sensitivity of local dopamine neurons to the stimulating effects of ethanol, Alcohol, vol.46, issue.3, pp.217-223, 2012.
DOI : 10.1016/j.alcohol.2011.11.007

S. R. Hauser, Nicotine Modulates Alcohol-Seeking and Relapse by Alcohol-Preferring (P) Rats in a Time-Dependent Manner, Alcoholism: Clinical and Experimental Research, vol.66, issue.1, pp.43-54, 2012.
DOI : 10.1111/j.1530-0277.2011.01579.x

H. M. Kamens, J. Andersen, and M. R. Picciotto, Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice, Psychopharmacology, vol.129, issue.1, pp.613-626, 2010.
DOI : 10.1007/s00213-009-1759-1

M. Ericson, A. Molander, E. Löf, J. A. Engel, and B. Söderpalm, Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors, European Journal of Pharmacology, vol.467, issue.1-3, pp.85-93, 2003.
DOI : 10.1016/S0014-2999(03)01564-4

A. Larsson, L. Svensson, B. Söderpalm, and J. A. Engel, Role of different nicotinic acetylcholine receptors in mediating behavioral and neurochemical effects of ethanol in mice, Alcohol, vol.28, issue.3, pp.157-167, 2002.
DOI : 10.1016/S0741-8329(02)00244-6

O. L. Patkar, A. Belmer, J. R. Tarren, J. Y. Holgate, and S. E. Bartlett, The effect of varenicline on binge-like ethanol consumption in mice is ??4 nicotinic acetylcholine receptor-independent, Neuroscience Letters, vol.633, pp.235-239, 2016.
DOI : 10.1016/j.neulet.2016.09.048

R. F. Leeman, Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes, Addiction Biology, vol.32, issue.2, pp.109-124, 2010.
DOI : 10.1111/j.1369-1600.2009.00192.x
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861719

C. Morel, Nicotine consumption is regulated by a human polymorphism in dopamine neurons, Molecular Psychiatry, vol.4, issue.8, pp.930-936, 2013.
DOI : 10.1016/S0896-6273(00)00042-8

C. Lüscher and R. C. Malenka, Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling, Neuron, vol.69, issue.4, pp.650-663, 2011.
DOI : 10.1016/j.neuron.2011.01.017

W. Xu, Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors, J. Neurosci, vol.19, pp.9298-9305, 1999.

M. R. Picciotto, Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain, Nature, vol.374, issue.6517, pp.65-67, 1995.
DOI : 10.1038/374065a0

S. G. Matta, Guidelines on nicotine dose selection for in vivo research, Psychopharmacology, vol.20, issue.Suppl 1, pp.269-319, 2007.
DOI : 10.1007/s00213-006-0441-0