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Integrative Bioinformatic Analysis of a Greek Epidemiological Cohort Provides Insight into the Pathogenesis of Primary Cutaneous Melanoma
Abstract : Melanoma is the most lethal type of skin cancer. In this study for the first time we analyze a Greek cohort of primary cutaneous melanoma biopsies, subjected to whole exome sequencing, in order to derive their mutational profile landscape. Moreover, in the context of big data analytical methodologies, we integrated the results of the exome sequencing analysis with transcriptomic data of cutaneous melanoma from GEO, in an attempt to perform a multi-layered analysis and infer a tentative disease network for primary melanoma pathogenesis. The purpose of this research is to incorporate different levels of molecular data, so as to expand our understanding of cutaneous melanoma and the broader molecular network implicated with this type of cancer. Overall, we showed that the results of the integrative analysis offer deeper insight in the underlying mechanisms affected by melanoma and could potentially contribute to the valuable effective epidemiological characterization of this disease.
Cited literature [22 references]
https://hal.inria.fr/hal-01557640
Contributor : Hal Ifip <>
Submitted on : Thursday, July 6, 2017 - 1:55:36 PM
Last modification on : Thursday, March 5, 2020 - 5:42:01 PM
Long-term archiving on: : Wednesday, January 24, 2018 - 1:22:55 AM
Contributor : Hal Ifip <>
Submitted on : Thursday, July 6, 2017 - 1:55:36 PM
Last modification on : Thursday, March 5, 2020 - 5:42:01 PM
Long-term archiving on: : Wednesday, January 24, 2018 - 1:22:55 AM
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430537_1_En_4_Chapter.pdf
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Distributed under a Creative Commons Attribution 4.0 International License