Multilevel Modeling with Structured Penalties for Classification from Imaging Genetics data

Pascal Lu 1 Olivier Colliot 1
1 ARAMIS - Algorithms, models and methods for images and signals of the human brain
UPMC - Université Pierre et Marie Curie - Paris 6, ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute, Inria de Paris
Abstract : In this paper, we propose a framework for automatic classification of patients from multimodal genetic and brain imaging data by optimally combining them. Additive models with unadapted penalties (such as the classical group lasso penalty or L_1-multiple kernel learning) treat all modalities in the same manner and can result in undesirable elimination of specific modalities when their contributions are unbalanced. To overcome this limitation, we introduce a multilevel model that combines imaging and genetics and that considers joint effects between these two modalities for diagnosis prediction. Furthermore, we propose a framework allowing to combine several penalties taking into account the structure of the different types of data, such as a group lasso penalty over the genetic modality and a L_2-penalty on imaging modalities. Finally , we propose a fast optimization algorithm, based on a proximal gradient method. The model has been evaluated on genetic (single nucleotide polymorphisms-SNP) and imaging (anatomical MRI measures) data from the ADNI database, and compared to additive models. It exhibits good performances in AD diagnosis; and at the same time, reveals relationships between genes, brain regions and the disease status.
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Submitted on : Tuesday, August 29, 2017 - 11:19:08 AM
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Pascal Lu, Olivier Colliot. Multilevel Modeling with Structured Penalties for Classification from Imaging Genetics data. 3rd MICCAI Workshop on Imaging Genetics (MICGen 2017), Sep 2017, Québec City, Canada. pp.230-240. ⟨hal-01578441⟩

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