Modeling CD4 + T cells dynamics in HIV-infected patients receiving repeated cycles of exogenous Interleukin 7

Abstract : Combination antiretroviral therapy succeeds to control viral replication in most HIV infected patients. This is normally followed by a reconstitution of the CD4+ T cells pool; however, this does not happen for all patients. For these patients, an immunotherapy based on injections of Interleukin 7 (IL-7) has been recently proposed in the hope of obtaining long-term reconstitution of the T cells pool. Several questions arise as to the long-term eciency of this treatment and the best protocol to apply. Mathematical and statistical models can help answering these questions.
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Submitted on : Wednesday, August 30, 2017 - 11:26:29 AM
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Ana Jarne, Daniel Commenges, Mélanie Prague, Yves Levy, Rodolphe Thiébaut. Modeling CD4 + T cells dynamics in HIV-infected patients receiving repeated cycles of exogenous Interleukin 7. Annals of Applied Statistics, Institute of Mathematical Statistics, 2017. ⟨hal-01579008⟩

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