Abstract : It has been suggested in the literature that a disorganization of cardiac tissue at the cellular scale may affect the propagation of the action potential (AP) at the tissue scale, and may play a role in arrhythmia. We developed a model of the myocardium at sub-cellular resolution in which the intracellular space, the cell membrane, and the extracellular space are discretized individually. We tested this approach on small, hand-crafted two- and three-dimensional networks of cells.
Pierre-Elliott Bécue, Mark Potse, Yves Coudière. A Three-Dimensional Computational Model of Action Potential Propagation Through a Network of Individual Cells. Computing in Cardiology 2017, Sep 2017, Rennes, France. pp.1-4. ⟨hal-01592178⟩