A Three-Dimensional Computational Model of Action Potential Propagation Through a Network of Individual Cells
Abstract
It has been suggested in the literature that a disorganization of cardiac tissue at the cellular scale may affect the propagation of the action potential (AP) at the tissue scale, and may play a role in arrhythmia. We developed a model of the myocardium at sub-cellular resolution in which the intracellular space, the cell membrane, and the extracellular space are discretized individually. We tested this approach on small, hand-crafted two- and three-dimensional networks of cells.
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