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A Three-Dimensional Computational Model of Action Potential Propagation Through a Network of Individual Cells

Pierre-Elliott Bécue 1, 2, 3 Mark Potse 1, 2 Yves Coudière 1, 2, 3
2 CARMEN - Modélisation et calculs pour l'électrophysiologie cardiaque
IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest, IHU-LIRYC
Abstract : It has been suggested in the literature that a disorganization of cardiac tissue at the cellular scale may affect the propagation of the action potential (AP) at the tissue scale, and may play a role in arrhythmia. We developed a model of the myocardium at sub-cellular resolution in which the intracellular space, the cell membrane, and the extracellular space are discretized individually. We tested this approach on small, hand-crafted two- and three-dimensional networks of cells.
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https://hal.inria.fr/hal-01592178
Contributor : Pierre-Elliott Bécue <>
Submitted on : Friday, September 22, 2017 - 5:29:59 PM
Last modification on : Saturday, May 18, 2019 - 9:38:02 PM
Document(s) archivé(s) le : Saturday, December 23, 2017 - 2:25:39 PM

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  • HAL Id : hal-01592178, version 1

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Pierre-Elliott Bécue, Mark Potse, Yves Coudière. A Three-Dimensional Computational Model of Action Potential Propagation Through a Network of Individual Cells. Computing in Cardiology 2017, Sep 2017, Rennes, France. pp.1-4. ⟨hal-01592178⟩

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