Biological Sequence Modeling with Convolutional Kernel Networks

Abstract : The growing number of annotated biological sequences available makes it possible to learn genotype-phenotype relationships from data with increasingly high accuracy. When large quantities of labeled samples are available for training a model, convolutional neural networks can be used to predict the phenotype of unannotated sequences with good accuracy. Unfortunately, their performance with medium- or small-scale datasets is mitigated, which requires inventing new data-efficient approaches. In this paper, we introduce a hybrid approach between convolutional neural networks and kernel methods to model biological sequences. Our method enjoys the ability of convolutional neural networks to learn data representations that are adapted to a specific task, while the kernel point of view yields algorithms that perform significantly better when the amount of training data is small. We illustrate these advantages for transcription factor binding prediction and protein homology detection, and we demonstrate that our model is also simple to interpret, which is crucial for discovering predictive motifs in sequences. The source code is freely available at https://gitlab.inria.fr/dchen/CKN-seq.
Type de document :
Article dans une revue
Bioinformatics, Oxford University Press (OUP), 2019
Liste complète des métadonnées

https://hal.inria.fr/hal-01632912
Contributeur : Julien Mairal <>
Soumis le : mardi 29 janvier 2019 - 16:05:53
Dernière modification le : jeudi 7 février 2019 - 19:06:42

Fichier

biorxiv.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

  • HAL Id : hal-01632912, version 3

Données associées

Collections

Citation

Dexiong Chen, Laurent Jacob, Julien Mairal. Biological Sequence Modeling with Convolutional Kernel Networks. Bioinformatics, Oxford University Press (OUP), 2019. 〈hal-01632912v3〉

Partager

Métriques

Consultations de la notice

59

Téléchargements de fichiers

66