Precision of manual two-dimensional segmentations of lung and liver metastases and its impact on tumour response assessment using RECIST 1.1

Abstract : Background: Response evaluation criteria in solid tumours (RECIST) has significant limitations in terms of variability and reproducibility, which may not be independent. The aim of the study was to evaluate the precision of manual bi-dimensional segmentation of lung, liver metastases, and to quantify the uncertainty in tumour response assessment. Methods: A total of 520 segmentations of metastases from six livers and seven lungs were independently performed by ten physicians and ten scientists on CT images, reflecting the variability encountered in clinical practice. Operators manually contoured the tumours, firstly independently according to the RECIST and secondly on a preselected slice. Diameters and areas were extracted from the segmentations. Mean standard deviations were used to build regression models and 95% confidence intervals (95% CI) were calculated for each tumour size and for limits of progressive disease (PD) and partial response (PR) derived from RECIST 1.1. Results: Thirteen aberrant segmentations (2.5%) were observed without significant differences between the physicians and scientists; only the mean area of liver tumours (p = 0.034) and mean diameter of lung tumours (p = 0.021) differed significantly. No difference was observed between the methods. Inter-observer agreement was excellent (intra-class correlation >0.90) for all variables. In liver, overlaps of the 95% CI with the 95% CI of limits of PD or PR were observed for diameters above 22.7 and 37.9 mm, respectively. An overlap of 95% CIs was systematically observed for area. No overlaps were observed in lung. Conclusions: Although the experience of readers might not affect the precision of segmentation in lung and liver, the results of manual segmentation performed for tumour response assessment remain uncertain for large liver metastases.
Type de document :
Article dans une revue
European Radiology Experimental, Springer, 2017, 1 (1), 〈10.1186/s41747-017-0015-4〉
Liste complète des métadonnées

Littérature citée [24 références]  Voir  Masquer  Télécharger

https://hal.inria.fr/hal-01634849
Contributeur : Olivier Saut <>
Soumis le : mardi 14 novembre 2017 - 14:43:59
Dernière modification le : jeudi 11 janvier 2018 - 06:27:21
Document(s) archivé(s) le : jeudi 15 février 2018 - 15:44:50

Fichier

s41747-017-0015-4.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

François Cornelis, Marie Martin, Olivier Saut, Xavier Buy, Michèle Kind, et al.. Precision of manual two-dimensional segmentations of lung and liver metastases and its impact on tumour response assessment using RECIST 1.1. European Radiology Experimental, Springer, 2017, 1 (1), 〈10.1186/s41747-017-0015-4〉. 〈hal-01634849〉

Partager

Métriques

Consultations de la notice

319

Téléchargements de fichiers

34