D. S. Goodsell and A. J. Olson, Structural Symmetry and Protein Function, Annual Review of Biophysics and Biomolecular Structure, vol.29, issue.1, pp.105-153, 2000.
DOI : 10.1146/annurev.biophys.29.1.105

E. D. Levy, J. B. Pereira-leal, C. Chothia, and S. A. Teichmann, 3D Complex: A Structural Classification of Protein Complexes, PLoS Computational Biology, vol.14, issue.11, p.155, 2006.
DOI : 10.1371/journal.pcbi.0020155.st002

D. B. Lukatsky, B. E. Shakhnovich, J. Mintseris, and E. Shakhnovich, Structural Similarity Enhances Interaction Propensity of Proteins, Journal of Molecular Biology, vol.365, issue.5, pp.1596-1606, 2007.
DOI : 10.1016/j.jmb.2006.11.020

I. Andre, C. E. Strauss, D. B. Kaplan, P. Bradley, and D. Baker, Emergence of symmetry in homooligomeric biological assemblies, Proceedings of the National Academy of Sciences, vol.77, issue.11, pp.16148-16152, 2008.
DOI : 10.1146/annurev.biochem.77.062906.171838

J. A. Marsh and S. A. Teichmann, Structure, Dynamics, Assembly, and Evolution of Protein Complexes, Annual Review of Biochemistry, vol.84, issue.1, pp.551-575, 2015.
DOI : 10.1146/annurev-biochem-060614-034142

S. E. Ahnert, J. A. Marsh, H. Hernandez, C. V. Robinson, and S. A. Teichmann, Principles of assembly reveal a periodic table of protein complexes, Science, vol.67, issue.Pt 4, p.2245, 2015.
DOI : 10.1107/S0907444910045749

I. M. Nooren and J. M. Thornton, NEW EMBO MEMBER'S REVIEW: Diversity of protein-protein interactions, The EMBO Journal, vol.22, issue.14, pp.3486-3492, 2003.
DOI : 10.1093/emboj/cdg359

S. Kuhner, Proteome Organization in a Genome-Reduced Bacterium, Science, vol.278, issue.5338, pp.1235-1240, 2009.
DOI : 10.1126/science.278.5338.631

T. Perica, The emergence of protein complexes: quaternary structure, dynamics and allostery, Biochemical Society Transactions, vol.9, issue.3, pp.475-491, 2012.
DOI : 10.1093/bioinformatics/btr163

M. Renatus, H. R. Stennicke, F. L. Scott, R. C. Liddington, and G. S. Salvesen, Dimer formation drives the activation of the cell death protease caspase 9, Proceedings of the National Academy of Sciences, vol.407, issue.6805, pp.14250-14255, 2001.
DOI : 10.1038/35037734

P. Tang, M. C. Hung, and J. Klostergaard, Human pro-Tumor Necrosis Factor Is a Homotrimer, Biochemistry, vol.35, issue.25, pp.8216-8225, 1996.
DOI : 10.1021/bi952182t

J. B. Pereira-leal, E. D. Levy, C. Kamp, and S. A. Teichmann, Evolution of protein complexes by duplication of homomeric interactions, Genome Biology, vol.8, issue.4, p.51, 2007.
DOI : 10.1186/gb-2007-8-4-r51

H. M. Berman, The Protein Data Bank, Nucleic Acids Research, vol.28, issue.1, pp.235-242, 2000.
DOI : 10.1093/nar/28.1.235

S. Velankar, PDBe: improved accessibility of macromolecular structure data from PDB and EMDB, Nucleic Acids Research, vol.44, issue.D1, pp.385-395, 2016.
DOI : 10.1093/nar/gkv1047

K. Henrick and J. M. Thornton, PQS: a protein quaternary structure file server, Trends in Biochemical Sciences, vol.23, issue.9, pp.358-361, 1998.
DOI : 10.1016/S0968-0004(98)01253-5

J. Janin, Specific versus non-specific contacts in protein crystals, Nature Structural Biology, vol.29, issue.12, pp.973-974, 1997.
DOI : 10.1073/pnas.93.1.13

O. Carugo and P. Argos, Protein-protein crystal-packing contacts, Protein Science, vol.29, issue.10, pp.2261-2263, 1997.
DOI : 10.1107/S0108768194011249

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2143556/pdf

H. Ponstingl, K. Henrick, and J. M. Thornton, Discriminating between homodimeric and monomeric proteins in the crystalline state, Proteins: Structure, Function, and Bioinformatics, vol.257, issue.1, pp.47-57, 2000.
DOI : 10.1017/CBO9780511802843

H. Zhu, F. S. Domingues, I. Sommer, and T. Lengauer, NOXclass: prediction of proteinprotein interaction types, BMC Bioinformatics, vol.7, issue.1, p.27, 2006.
DOI : 10.1186/1471-2105-7-27

E. Krissinel and K. Henrick, Inference of Macromolecular Assemblies from Crystalline State, Journal of Molecular Biology, vol.372, issue.3, pp.774-797, 2007.
DOI : 10.1016/j.jmb.2007.05.022

J. Bernauer, R. P. Bahadur, F. Rodier, J. Janin, and A. Poupon, DiMoVo: a Voronoi tessellation-based method for discriminating crystallographic and biological protein-protein interactions, Bioinformatics, vol.24, issue.5, pp.652-658, 2008.
DOI : 10.1093/bioinformatics/btn022

URL : https://hal.archives-ouvertes.fr/inria-00431696

Y. Tsuchiya, H. Nakamura, and K. Kinoshita, Discrimination between biological interfaces and crystal-packing contacts, Advances and Applications in Bioinformatics and Chemistry, vol.1, pp.99-113, 2008.
DOI : 10.2147/AABC.S4255

URL : https://doi.org/10.2147/aabc.s4255

R. P. Bahadur, P. Chakrabarti, F. Rodier, and J. Janin, A Dissection of Specific and Non-specific Protein???Protein Interfaces, Journal of Molecular Biology, vol.336, issue.4, pp.943-955, 2004.
DOI : 10.1016/j.jmb.2003.12.073

A. Pal, P. Chakrabarti, R. Bahadur, F. Rodier, and J. Janin, Peptide segments in protein-protein interfaces, Journal of Biosciences, vol.3, issue.1, pp.101-111, 2007.
DOI : 10.1007/s12038-007-0010-7

K. G. Tina, R. Bhadra, and N. Srinivasan, PIC: Protein Interactions Calculator, Nucleic Acids Research, vol.35, issue.Web Server, pp.473-476, 2007.
DOI : 10.1093/nar/gkm423

URL : https://academic.oup.com/nar/article-pdf/35/suppl_2/W473/9587798/gkm423.pdf

Q. Liu, Z. Li, and J. Li, Use B-factor related features for accurate classification between protein binding interfaces and crystal packing contacts, BMC Bioinformatics, vol.15, issue.Suppl 16, p.3, 2014.
DOI : 10.1073/pnas.93.26.15018

URL : https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/1471-2105-15-S16-S3?site=bmcbioinformatics.biomedcentral.com

A. H. Elcock and J. A. Mccammon, Identification of protein oligomerization states by analysis of interface conservation, Proceedings of the National Academy of Sciences, vol.287, issue.5456, pp.2990-2994, 2001.
DOI : 10.1126/science.287.5456.1279

M. Guharoy and P. Chakrabarti, Conservation and relative importance of residues across protein-protein interfaces, Proceedings of the National Academy of Sciences, vol.11, issue.4, pp.15447-15452, 2005.
DOI : 10.1002/prot.340110407

M. A. Scharer, M. G. Grutter, and G. Capitani, CRK: An evolutionary approach for distinguishing biologically relevant interfaces from crystal contacts, Proteins: Structure, Function, and Bioinformatics, vol.297, issue.Part 1, pp.2707-2713, 2010.
DOI : 10.1002/prot.22787

K. Baskaran, J. M. Duarte, N. Biyani, S. Bliven, and G. Capitani, A PDB-wide, evolution-based assessment of protein-protein interfaces, BMC Structural Biology, vol.25, issue.17, p.22, 2014.
DOI : 10.1093/nar/25.17.3389

H. Ashkenazy, ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules, Nucleic Acids Research, vol.44, issue.W1, pp.344-350, 2016.
DOI : 10.1093/nar/gkw408

Q. Xu, Statistical Analysis of Interface Similarity in Crystals of Homologous Proteins, Journal of Molecular Biology, vol.381, issue.2, pp.487-507, 2008.
DOI : 10.1016/j.jmb.2008.06.002

Q. Xu, R. L. Dunbrack, and . Jr, The protein common interface database (ProtCID)--a comprehensive database of interactions of homologous proteins in multiple crystal forms, Nucleic Acids Research, vol.39, issue.Database, pp.761-770, 2011.
DOI : 10.1093/nar/gkq1059

B. A. Shoemaker, IBIS (Inferred Biomolecular Interaction Server) reports, predicts and integrates multiple types of conserved interactions for proteins, Nucleic Acids Research, vol.40, issue.D1, pp.834-840, 2012.
DOI : 10.1093/nar/gkr997

G. Faure, J. Andreani, and R. Guerois, InterEvol database: exploring the structure and evolution of protein complex interfaces, Nucleic Acids Research, vol.40, issue.D1, pp.847-856, 2012.
DOI : 10.1093/nar/gkr845

M. J. Sippl and M. Wiederstein, Detection of Spatial Correlations in Protein Structures and Molecular Complexes, Structure, vol.20, issue.4, pp.718-728, 2012.
DOI : 10.1016/j.str.2012.01.024

R. Koike and M. Ota, SCPC: a method to structurally compare protein complexes, Bioinformatics, vol.28, issue.3, pp.324-330, 2012.
DOI : 10.1093/bioinformatics/btr654

URL : https://academic.oup.com/bioinformatics/article-pdf/28/3/324/16907691/btr654.pdf

S. Mukherjee and Y. Zhang, MM-align: a quick algorithm for aligning multiple-chain protein complex structures using iterative dynamic programming, Nucleic Acids Research, vol.37, issue.11, p.37, 2009.
DOI : 10.1093/nar/gkp318

URL : https://academic.oup.com/nar/article-pdf/37/11/e83/16754820/gkp318.pdf

D. W. Ritchie, A. W. Ghoorah, L. Mavridis, and V. Venkatraman, Fast protein structure alignment using Gaussian overlap scoring of backbone peptide fragment similarity, Bioinformatics, vol.28, issue.24, pp.3274-3281, 2012.
DOI : 10.1093/bioinformatics/bts618

URL : https://hal.archives-ouvertes.fr/hal-00756813

Y. Zhang and J. Skolnick, TM-align: a protein structure alignment algorithm based on the TM-score, Nucleic Acids Research, vol.33, issue.7, pp.2302-2309, 2005.
DOI : 10.1093/nar/gki524

T. Perica, C. Chothia, and S. A. Teichmann, Evolution of oligomeric state through geometric coupling of protein interfaces, Proceedings of the National Academy of Sciences, vol.284, issue.38, pp.8127-8132, 2012.
DOI : 10.1074/jbc.M109.001826

I. H. Moal and J. Fernandez-recio, SKEMPI: a Structural Kinetic and Energetic database of Mutant Protein Interactions and its use in empirical models, Bioinformatics, vol.28, issue.20, pp.2600-2607, 2012.
DOI : 10.1093/bioinformatics/bts489

J. Andreani, G. Faure, and R. Guerois, Versatility and Invariance in the Evolution of Homologous Heteromeric Interfaces, PLoS Computational Biology, vol.8, issue.8, p.1002677, 2012.
DOI : 10.1371/journal.pcbi.1002677.s003

G. Sudha, P. Singh, L. S. Swapna, and N. Srinivasan, Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes, Protein Science, vol.2, issue.11, pp.1856-1873, 2015.
DOI : 10.1038/srep00334

Z. Shi and J. Moult, Structural and Functional Impact of Cancer-Related Missense Somatic Mutations, Journal of Molecular Biology, vol.413, issue.2, pp.495-512, 2011.
DOI : 10.1016/j.jmb.2011.06.046

A. David and M. J. Sternberg, The Contribution of Missense Mutations in Core and Rim Residues of Protein???Protein Interfaces to Human Disease, Journal of Molecular Biology, vol.427, issue.17, pp.2886-2898, 2015.
DOI : 10.1016/j.jmb.2015.07.004

H. Garcia-seisdedos, C. Empereur-mot, N. Elad, and E. D. Levy, Proteins evolve on the edge of supramolecular self-assembly, Nature, vol.548, pp.244-247, 2017.

J. D. Bloom, D. A. Drummond, F. H. Arnold, and C. Wilke, Structural Determinants of the Rate of Protein Evolution in Yeast, Molecular Biology and Evolution, vol.23, issue.9, pp.1751-1761, 2006.
DOI : 10.1093/molbev/msl040

G. Minasov, Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP, Proceedings of the National Academy of Sciences, vol.64, issue.1, pp.6328-6333, 2000.
DOI : 10.1016/S0076-6879(97)77027-7

E. D. Levy, E. Boeri-erba, C. V. Robinson, and S. A. Teichmann, Assembly reflects evolution of protein complexes, Nature, vol.2, issue.7199, pp.1262-1265, 2008.
DOI : 10.1038/nature06942

X. Robin, pROC: an open-source package for R and S+ to analyze and compare ROC curves, BMC Bioinformatics, vol.12, issue.1, p.77, 2011.
DOI : 10.1007/s00134-009-1641-y

R. P. Bahadur, P. Chakrabarti, F. Rodier, and J. Janin, Dissecting subunit interfaces in homodimeric proteins, Proteins: Structure, Function, and Genetics, vol.11, issue.3, pp.708-719, 2003.
DOI : 10.1002/prot.10461

J. M. Duarte, A. Srebniak, M. A. Scharer, and G. Capitani, Protein interface classification by evolutionary analysis, BMC Bioinformatics, vol.13, issue.1, p.334, 2012.
DOI : 10.1002/prot.10461

URL : https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/1471-2105-13-334?site=bmcbioinformatics.biomedcentral.com

E. D. Levy, A Simple Definition of Structural Regions in Proteins and Its Use in Analyzing Interface Evolution, Journal of Molecular Biology, vol.403, issue.4, pp.660-670, 2010.
DOI : 10.1016/j.jmb.2010.09.028

B. E. Suzek, UniRef clusters: a comprehensive and scalable alternative for improving sequence similarity searches, Bioinformatics, vol.31, issue.6, pp.926-932, 2015.
DOI : 10.1093/bioinformatics/btu739

URL : https://academic.oup.com/bioinformatics/article-pdf/31/6/926/569379/btu739.pdf

R. C. Edgar, MUSCLE: multiple sequence alignment with high accuracy and high throughput, Nucleic Acids Research, vol.32, issue.5, pp.1792-1797, 2004.
DOI : 10.1093/nar/gkh340

URL : https://academic.oup.com/nar/article-pdf/32/5/1792/7055030/gkh340.pdf

T. Pupko, R. E. Bell, I. Mayrose, F. Glaser, and N. Ben-tal, Rate4Site: an algorithmic tool for the identification of functional regions in proteins by surface mapping of evolutionary determinants within their homologues, Bioinformatics, vol.18, issue.Suppl 1, pp.71-77, 2002.
DOI : 10.1093/bioinformatics/18.suppl_1.S71

S. Dey, A. Pal, P. Chakrabarti, and J. Janin, The Subunit Interfaces of Weakly Associated Homodimeric Proteins, Journal of Molecular Biology, vol.398, issue.1, pp.146-160, 2010.
DOI : 10.1016/j.jmb.2010.02.020