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Poster communications

Towards the assessment of myelination using time-dependent diffusion MRI indices

Abstract : Synopsis We study the sensitivity of time-dependent diffusion MRI indices or qτ-indices to demyelination in the mouse brain. For this, we acquire in vivo four-dimentional diffusion-weighted images-varying over gradient strength, direction and diffusion time-and estimate the qτ-indices from the corpus callosum. First order Taylor approximation of each index gives fitting coefficients α and β whose variance we investigate. Results indicate that, cuprizone intoxication affects mainly index coefficient β by introducing inequality of variances between the two mice groups, most significantly in the splenium and that MSD increases and RTOP decreases over diffusion time τ.
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Poster communications
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Submitted on : Monday, March 5, 2018 - 5:54:59 PM
Last modification on : Friday, September 2, 2022 - 12:36:11 PM
Long-term archiving on: : Wednesday, June 6, 2018 - 4:53:55 PM


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  • HAL Id : hal-01723846, version 1


Abib Alimi, Alexandra Petiet, Mathieu Santin, Anne-Charlotte Philippe, Stéphane Lehéricy, et al.. Towards the assessment of myelination using time-dependent diffusion MRI indices. ISMRM 2018 - International Society for Magnetic Resonance in Medicine, Jun 2018, Paris, France. pp.1-4. ⟨hal-01723846⟩



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