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Model-based Feature Augmentation for Cardiac Ablation Target Learning from Images

Abstract : Goal: We present a model-based feature augmentation scheme to improve the performance of a learning algorithm for the detection of cardiac radio-frequency ablation (RFA) targets with respect to learning from images alone. Methods: Initially, we compute image features from delayed-enhanced MRI (DE-MRI) to describe local tissue heterogeneities and feed them into a machine learning framework with uncertainty assessment for the identification of potential ablation targets. Next, we introduce the use of a patient-specific image-based model derived from DE-MRI coupled with the Mitchell-Schaeffer electrophysiology model and a dipole formulation for the simulation of intracardiac electrograms (EGM). Relevant features are extracted from these simulated signals which serve as a feature augmentation scheme for the learning algorithm. We assess the classifier's performance when using only image features and with model-based feature augmentation. Results: We obtained average classification scores of 97.2% accuracy, 82.4% sensitivity and 95.0% positive predictive value (PPV) by using a model-based feature augmentation scheme. Preliminary results also show that training the algorithm on the closest patient from the database, instead of using all the patients, improves the classification results. Conclusion: We presented a feature augmentation scheme based on biophysical cardiac electrophysiology modeling to increase the prediction scores of a machine learning framework for the RFA target prediction. Significance: The results derived from this study are a proof of concept that the use of model-based feature augmentation strengthens the performance of a purely image driven learning scheme for the prediction of cardiac ablation targets.
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Submitted on : Monday, May 7, 2018 - 2:07:51 PM
Last modification on : Thursday, February 7, 2019 - 2:24:49 PM
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Rocio Cabrera Lozoya, Benjamin Berte, Hubert Cochet, Pierre Jaïs, Nicholas Ayache, et al.. Model-based Feature Augmentation for Cardiac Ablation Target Learning from Images. IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers, 2018, pp.1. ⟨10.1109/TBME.2018.2818300⟩. ⟨hal-01744142⟩



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