This article adapts the framework of metamorphosis to the resolution of inverse problems with shape prior. The metamorphosis framework allows to transform an image via a balance between geometrical deformations and changes in intensities (that can for instance correspond to the appearance of a new structure). The idea developed here is to reconstruct an image from noisy and indirect observations by registering, via metamorphosis, a template to the observed data. Unlike a registration with only geometrical changes, this framework gives good results when intensities of the template are poorly chosen. We show that this method is a well-defined regularization method (proving existence, stability and convergence) and present several numerical examples.