In this paper, the reduction method is extended to time-delay systems affected by two mismatched input delays. To this end, the intrinsic feedback structure of the retarded dynamics is exploited to deduce a reduced dynamics which is free of delays. Moreover, among other possibilities, an Immersion and Invariance feedback over the reduced dynamics is designed for achieving stabilization of the original dynamics. A chained sampled-data dynamics is used to show the effectiveness of the proposed control strategy through simulations.