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Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development

Abstract : Increasing age is the biggest risk factor for dementia, of which Alzheimer’s disease is the commonest cause. The pathological changes underpinning Alzheimer’s disease are thought to develop at least a decade prior to the onset of symptoms. Molecular positron emission tomography and multi-modal magnetic resonance imaging allow key pathological processes underpinning cognitive impairment – including β-amyloid depostion, vascular disease, network breakdown and atrophy – to be assessed repeatedly and non-invasively. This enables potential determinants of dementia to be delineated earlier, and therefore opens a pre-symptomatic window where intervention may prevent the onset of cognitive symptoms.
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https://hal.inria.fr/hal-01827191
Contributor : Ninon Burgos <>
Submitted on : Sunday, July 1, 2018 - 10:42:14 PM
Last modification on : Wednesday, July 7, 2021 - 10:26:36 AM

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Christopher A. Lane, Thomas D. Parker, Dave M. Cash, Kirsty Macpherson, Elizabeth Donnachie, et al.. Study protocol: Insight 46 – a neuroscience sub-study of the MRC National Survey of Health and Development. BMC Neurology, BioMed Central, 2017, 17, pp.75. ⟨10.1186/s12883-017-0846-x⟩. ⟨hal-01827191⟩

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