Skip to Main content Skip to Navigation
Journal articles

Using florbetapir positron emission tomography to explore cerebrospinal fluid cut points and gray zones in small sample sizes

Abstract : Introduction We aimed to assess the feasibility of determining Alzheimer's disease cerebrospinal fluid (CSF) cut points in small samples through comparison with amyloid positron emission tomography (PET). Methods Twenty-three individuals (19 patients, four controls) had CSF measures of amyloid beta (Aβ)1–42 and total tau/Aβ1–42 ratio, and florbetapir PET. We compared CSF measures with visual and quantitative (standardized uptake value ratio [SUVR]) PET measures of amyloid. Results Seventeen of 23 were amyloid-positive on visual reads, and 14 of 23 at an SUVR of ≥1.1. There was concordance (positive/negative on both measures) in 20 of 23, of whom 19 of 20 were correctly classified at an Aβ1–42 of 630 ng/L, and 20 of 20 on tau/Aβ1–42 ratio (positive ≥0.88; negative ≤0.34). Three discordant cases had Aβ1–42 levels between 403 and 729 ng/L and tau/Aβ1–42 ratios of 0.54–0.58. Discussion Comparing amyloid PET and CSF biomarkers provides a means of assessing CSF cut points in vivo, and can be applied to small sample sizes. CSF tau/Aβ1–42 ratio appears robust at predicting amyloid status, although there are gray zones where there remains diagnostic uncertainty.
Document type :
Journal articles
Complete list of metadata

https://hal.inria.fr/hal-01827214
Contributor : Ninon Burgos <>
Submitted on : Sunday, July 1, 2018 - 10:42:55 PM
Last modification on : Friday, December 4, 2020 - 2:30:01 PM

Links full text

Identifiers

Citation

Philip S. J. Weston, Ross W. Paterson, Marc Modat, Ninon Burgos, Manuel J. Cardoso, et al.. Using florbetapir positron emission tomography to explore cerebrospinal fluid cut points and gray zones in small sample sizes. Alzheimer's and Dementia, Elsevier, 2015, 1 (4), pp.440--446. ⟨10.1016/j.dadm.2015.10.001⟩. ⟨hal-01827214⟩

Share

Metrics

Record views

27