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Attenuation correction synthesis for hybrid PET-MR scanners

Abstract : The combination of functional and anatomical imaging technologies such as Positron Emission Tomography (PET) and Computed Tomography (CT) has shown its value in the preclinical and clinical fields. In PET/CT hybrid acquisition systems, CT-derived attenuation maps enable a more accurate PET reconstruction. However, CT provides only very limited soft-tissue contrast and exposes the patient to an additional radiation dose. In comparison, Magnetic Resonance Imaging (MRI) provides good soft-tissue contrast and the ability to study functional activation and tissue microstructures, but does not directly provide patient-specific electron density maps for PET reconstruction.The aim of the proposed work is to improve PET/MR reconstruction by generating synthetic CTs and attenuation-maps. The synthetic images are generated through a multi-atlas information propagation scheme, locally matching the MRI-derived patient’s morphology to a database of pre-acquired MRI/CT pairs. Results show improvements in CT synthesis and PET reconstruction accuracy when compared to a segmentation method using an Ultrashort-Echo-Time MRI sequence.
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https://hal.inria.fr/hal-01827223
Contributor : Ninon Burgos <>
Submitted on : Sunday, July 1, 2018 - 10:43:15 PM
Last modification on : Friday, December 4, 2020 - 2:30:01 PM

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Ninon Burgos, Manuel Jorge Cardoso, Marc Modat, Stefano Pedemonte, John Dickson, et al.. Attenuation correction synthesis for hybrid PET-MR scanners. Medical Image Computing and Computer-Assisted Intervention – MICCAI 2013, Sep 2013, Nagoya, Japan. pp.147--154, ⟨10.1007/978-3-642-40811-3_19⟩. ⟨hal-01827223⟩

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