Introducing Cell-Plasticity Mechanisms into a Class of Cell Population Dynamical Systems

Walid Djema 1, 2 Catherine Bonnet 2, 1 Frédéric Mazenc 2 Jean Clairambault 3
2 DISCO - Dynamical Interconnected Systems in COmplex Environments
L2S - Laboratoire des signaux et systèmes, Inria Saclay - Ile de France, SUPELEC, CNRS - Centre National de la Recherche Scientifique : UMR8506
3 MAMBA - Modelling and Analysis for Medical and Biological Applications
Inria de Paris, LJLL - Laboratoire Jacques-Louis Lions
Abstract : Cells have amazing features that allow them to guide their development paths and determine their individual and collective fates. Dedifferentia-tion and transdifferentiation (cell plasticity) are little-understood phenomena that allow cells to regress from an advanced differentiated state to a less differentiated one, including the case where cells lose their specific function and become stem cells. In this paper, we introduce cell plasticity into a class of mathematical models we are interested in. We explore a new model involving a dedifferentiation function in the case of two cell maturity stages (stem cells and progeny). We highlight the role that dedifferentiation may have in the survival of cancer cells during therapy. The latter hypothesis appears to be in line with some medical observations.
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Walid Djema, Catherine Bonnet, Frédéric Mazenc, Jean Clairambault. Introducing Cell-Plasticity Mechanisms into a Class of Cell Population Dynamical Systems. IEEE American Control Conference (ACC 2018), Jun 2018, Milwaukee, United States. ⟨10.23919/acc.2018.8430758 ⟩. ⟨hal-01848890⟩

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