Skip to Main content Skip to Navigation
Journal articles

Dopamine-endocannabinoid interactions mediate spike-timing dependent potentiation in the striatum

Abstract : Dopamine modulates striatal synaptic plasticity, a key substrate for action selection and procedural learning. Thus, characterizing the repertoire of activity-dependent plasticity in striatum and its dependence on dopamine is of crucial importance. We recently unraveled a striatal spike-timing-dependent long-term potentiation (tLTP) mediated by endocannabinoids (eCBs) and induced with few spikes (~5-15). Whether this eCB-tLTP interacts with the dopaminergic system remains to be investigated. Here, we report that eCB-tLTP is impaired in a rodent model of Parkinson's disease and rescued by L-DOPA. Dopamine controls eCB-tLTP via dopamine type-2 receptors (D 2 R) located presynaptically in cortical terminals. Dopamine-endocannabinoid interactions via D 2 R are required for the emergence of tLTP in response to few coincident pre-and post-synaptic spikes and control eCB-plasticity by modulating the long-term potentiation (LTP)/depression (LTD) thresholds. While usually considered as a depressing synaptic function, our results show that eCBs in the presence of dopamine constitute a versatile system underlying bidirectional plasticity implicated in basal ganglia pathophysiology.
Complete list of metadata

Cited literature [74 references]  Display  Hide  Download
Contributor : Hugues Berry Connect in order to contact the contributor
Submitted on : Monday, October 8, 2018 - 4:25:31 PM
Last modification on : Friday, October 15, 2021 - 1:40:08 PM


Xu2018NatureComm (1).pdf
Files produced by the author(s)



Hao Xu, Sylvie Pérez, Amandine Cornil, Bérangère Detraux, Ilya Prokin, et al.. Dopamine-endocannabinoid interactions mediate spike-timing dependent potentiation in the striatum. Nature Communications, Nature Publishing Group, 2018, 9, pp.4118. ⟨10.1038/s41467-018-06409-5⟩. ⟨hal-01865929v2⟩



Record views


Files downloads