Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue RSC Advances Année : 2018

Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing

Marie Pierdant
  • Fonction : Auteur
  • PersonId : 1036339
Dominique Bagnard
  • Fonction : Auteur
  • PersonId : 960582

Résumé

Recently, it has been shown that the efficiency of antitumoral drugs can be enhanced when combined with therapeutic siRNAs. In the present study, an original platform based on polydiacetylenic micelles containing a cationic head group able to efficiently deliver a small interfering RNA (siRNA) targeting the PLK-1 gene while offering a hydrophobic environment for encapsulation of lipophilic drugs such as camptothecin is developed. We demonstrate that the co-delivery of these two agents with our micellar system results in a synergistic tumor cell killing of cervical and breast cancer cell lines in vitro. The combined drugs are active in a subcutaneous in vivo cancer model. Altogether, the results show that our nanometric micellar delivery system can be used for the development of new drug–siRNA combo-therapies.

Domaines

Autre [q-bio.OT]
Fichier principal
Vignette du fichier
co-delivery.pdf (1.41 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01872460 , version 1 (19-09-2018)

Identifiants

Citer

Manon Ripoll, Marie Pierdant, Patrick Neuberg, Dominique Bagnard, Alain Wagner, et al.. Co-delivery of anti-PLK-1 siRNA and camptothecin by nanometric polydiacetylenic micelles results in a synergistic cell killing. RSC Advances, 2018, 8 (37), pp.20758-20763. ⟨10.1039/C8RA03375G⟩. ⟨hal-01872460⟩
70 Consultations
59 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More