Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture

Abstract : Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer (NK) cells. Binding of KIR3DS1 to its recently discovered ligand, HLA-F, activates NK cells and has been associated with resolution of hepatitis C virus (HCV) infection. We investigated the mechanisms by which KIR3DS1 contributes to the antiviral immune response. Using cell culture systems, mice with humanized livers , and primary liver tissue from HCV-infected individuals, we found that the KIR3DS1 ligand HLA-F is upregulated on HCV-infected cells, and that interactions between KIR3DS1 and HLA-F contribute to NK cell-mediated control of HCV. Strategies to promote interaction between KIR3DS1 and HLA-F might be developed for treatment of infectious diseases and cancer.
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Submitted on : Friday, October 5, 2018 - 2:29:11 PM
Last modification on : Thursday, February 7, 2019 - 4:31:27 PM

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Sebastian Lunemann, Anja Schöbel, Janine Kah, Pia Fittje, Angelique Hölzemer, et al.. Interactions Between KIR3DS1 and HLA-F Activate Natural Killer Cells to Control HCV Replication in Cell Culture. Gastroenterology, WB Saunders, 2018, ⟨10.1053/j.gastro.2018.07.019⟩. ⟨hal-01888904⟩

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