B. Gustavsson, A review of the evolution of systemic chemotherapy in the management of colorectal cancer, Clinical Colorectal Cancer, vol.14, pp.1-10, 2015.

T. Armaghany, J. D. Wilson, Q. Chu, and G. Mills, Genetic alterations in colorectal cancer, Gastrointestinal cancer research: GCR, vol.5, pp.19-27, 2012.

K. Nakamoto, Expression of E-cadherin and KRAS mutation may serve as biomarkers of cetuximab-based therapy in metastatic colorectal cancer, Oncology Letters, vol.5, pp.1295-1300, 2013.

E. Van-cutsem, ESMO consensus guidelines for the management of patients with metastatic colorectal cancer, Annals of Oncology: Official Journal of the European Society for Medical Oncology, vol.27, pp.1386-1422, 2016.

B. O. Emburgh, Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer, Nature Communications, vol.7, p.13665, 2016.

E. Van-cutsem, Imaging in Colorectal Cancer: Progress and Challenges for the Clinicians, Cancers, vol.8, 2016.

D. T. Le, PD-1 Blockade in Tumors with Mismatch-Repair Deficiency, New England Journal of Medicine, vol.372, pp.2509-2520, 2015.

M. J. Overman, Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study, The Lancet. Oncology, vol.18, pp.1182-1191, 2017.

C. Cremolini, FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study, The Lancet. Oncology, vol.16, pp.1306-1315, 2015.

J. Mclean, Clinical Practice Patterns in Chemotherapeutic Treatment Regimens for Metastatic Colorectal Cancer, Clinical Colorectal Cancer, vol.15, pp.135-140, 2016.

Y. Ohhara, Role of targeted therapy in metastatic colorectal cancer, World Journal of Gastrointestinal Oncology, vol.8, pp.642-655, 2016.

J. Guinney, The consensus molecular subtypes of colorectal cancer, Nature Medicine, vol.21, pp.1350-1356, 2015.

J. M. Keck, Cyclin E overexpression impairs progression through mitosis by inhibiting APCCdh1, The Journal of Cell Biology, vol.178, pp.371-385, 2007.

N. L. Lehman, Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors, The American Journal of Pathology, vol.170, pp.1793-1805, 2007.

A. Schreiber, Structural basis for the subunit assembly of the anaphase-promoting complex, Nature, vol.470, pp.227-232, 2011.

L. Chang, Z. Zhang, J. Yang, S. H. Mclaughlin, and D. Barford, Molecular architecture and mechanism of the anaphase-promoting complex, Nature, vol.513, pp.388-393, 2014.

Z. Zhou, M. He, A. A. Shah, and Y. Wan, Insights into APC/C: from cellular function to diseases and therapeutics, Cell Division, vol.11, p.9, 2016.

I. Kikuchi, Y. Nakayama, T. Morinaga, Y. Fukumoto, and N. Yamaguchi, A decrease in cyclin B1 levels leads to polyploidization in DNA damage-induced senescence, Cell Biology International, vol.34, pp.645-653, 2010.

M. Mora-santos, A single mutation in Securin induces chromosomal instability and enhances cell invasion, European Journal of Cancer, vol.49, pp.500-510, 1990.

Z. Tang, APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphasepromoting complex, Molecular Biology of the Cell, vol.12, pp.3839-3851, 2001.

A. Kelly, K. E. Wickliffe, L. Song, I. Fedrigo, and M. Rape, Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate, Molecular Cell, vol.56, pp.232-245, 2014.

D. Izawa and J. Pines, The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C, Nature, vol.517, pp.631-634, 2015.

S. J. Suijkerbuijk, Molecular causes for BUBR1 dysfunction in the human cancer predisposition syndrome mosaic variegated aneuploidy, Cancer Research, vol.70, pp.4891-4900, 2010.

K. Park, S. Choi, M. Eom, and Y. Kang, Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships, Breast Cancer Research, vol.7, pp.238-247, 2005.

Q. Wang, Alterations of anaphase-promoting complex genes in human colon cancer cells, Oncogene, vol.22, pp.1486-1490, 2003.

F. Bertucci, Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters, Oncogene, vol.23, pp.1377-1391, 2004.
URL : https://hal.archives-ouvertes.fr/hal-01612151

F. A. Sinicrope, DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracil-based adjuvant therapy, Journal of the National Cancer Institute, vol.103, pp.863-875, 2011.

L. Sansregret, APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability, Cancer Discovery, vol.7, pp.218-233, 2017.

J. Barretina, The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity, Nature, vol.483, pp.603-607, 2012.

, The Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer, Nature, vol.487, pp.330-337, 2012.

S. K. Shin, Epigenetic and genetic alterations in Netrin-1 receptors UNC5c and DCC in human colon cancer, Gastroenterology, vol.133, pp.1849-1857, 2007.

C. V. Rao and H. Y. Yamada, Genomic instability and colon carcinogenesis: from the perspective of genes, Frontiers in Oncology, vol.3, p.130, 2013.

A. J. Lee, Chromosomal instability confers intrinsic multidrug resistance, Cancer Research, vol.71, pp.1858-1870, 2011.

L. Poincloux, Loss of Bcl-2 expression in colon cancer: a prognostic factor for recurrence in stage II colon cancer, Surgical Oncology, vol.18, pp.357-365, 2009.

H. N. Choi, Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/betacatenin complex, Oncology Reports, vol.21, pp.57-63, 2009.

A. Ercilla, New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress, Nucleic Acids Research, vol.44, pp.4745-4762, 2016.

Q. Xie, CDC20 maintains tumor initiating cells, Oncotarget, vol.6, pp.13241-13254, 2015.

Y. Shi and K. Huo, Knockdown expression of Apc11 leads to cell-cycle distribution reduction in G2/M phase, Genetics and molecular research: GMR, vol.11, pp.2814-2822, 2012.

K. G. Wirth, Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation, Genes & Development, vol.18, pp.88-98, 2004.

L. A. Passmore, The anaphase-promoting complex (APC): the sum of its parts?, Biochemical Society Transactions, vol.32, pp.724-727, 2004.

, SCientifiC RepoRts |, vol.8, 2018.

A. M. Wehman, W. Staub, and H. Baier, The anaphase-promoting complex is required in both dividing and quiescent cells during zebrafish development, Developmental Biology, vol.303, pp.144-156, 2007.

L. Qiu, Downregulation of CDC27 inhibits the proliferation of colorectal cancer cells via the accumulation of p21cip1/Waf1, Cell Death & Disease, vol.7, p.2074, 2016.

M. S. Lawrence, Discovery and saturation analysis of cancer genes across 21 tumour types, Nature, vol.505, pp.495-501, 2014.

Y. He, L. Tollini, T. Kim, Y. Itahana, and Y. Zhang, The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2, Cell Cycle, vol.13, pp.2101-2109, 2014.

T. Banerjee, S. Nath, and S. Roychoudhury, DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling, Nucleic Acids Research, vol.37, pp.2688-2698, 2009.

P. Van-der-lelij, SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs, The EMBO journal, vol.33, pp.2643-2658, 2014.

J. Peters, The anaphase-promoting complex: proteolysis in mitosis and beyond, Molecular Cell, vol.9, pp.931-943, 2002.

J. Peters, The anaphase promoting complex/cyclosome: a machine designed to destroy, Nature Reviews. Molecular Cell Biology, vol.7, pp.644-656, 2006.

J. A. Pesin and T. L. Orr-weaver, Regulation of APC/C activators in mitosis and meiosis, Annual Review of Cell and Developmental Biology, vol.24, pp.475-499, 2008.

J. Pines, Cubism and the cell cycle: the many faces of the APC/C, Nature Reviews. Molecular Cell Biology, vol.12, pp.427-438, 2011.

A. Mohd-sarip, Transcription-independent function of Polycomb group protein PSC in cell cycle control, Science, vol.336, pp.744-747, 2012.

S. Giovinazzi, D. Bellapu, V. M. Morozov, and A. M. Ishov, Targeting mitotic exit with hyperthermia or APC/C inhibition to increase paclitaxel efficacy, Cell Cycle, vol.12, pp.2598-2607, 2013.

K. L. Sackton, Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C, Nature, vol.514, pp.646-649, 2014.

J. Gayet, Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines, Oncogene, vol.20, pp.5025-5032, 2001.

J. F. Cajot, I. Sordat, T. Silvestre, and B. Sordat, Differential display cloning identifies motility-related protein (MRP1/CD9) as highly expressed in primary compared to metastatic human colon carcinoma cells, Cancer Research, vol.57, pp.2593-2597, 1997.

J. Combes, Contribution of cell culture, RNA extraction, and reverse transcription to the measurement error in quantitative reverse transcription polymerase chain reaction-based gene expression quantification, Analytical Biochemistry, vol.393, pp.29-35, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00539350

G. Grelier, Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype, British Journal of Cancer, vol.101, pp.673-683, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00539351

D. J. Sargent, Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer, Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, vol.28, pp.3219-3226, 2010.

J. Perrin, MSH2 and MLH1 immunodetection and the prognosis of colon cancer, International Journal of Oncology, vol.19, pp.891-895, 2001.

C. Ginestier, Distinct and Complementary Information Provided by Use of Tissue and DNA Microarrays in the Study of Breast Tumor Markers, The American Journal of Pathology, vol.161, pp.1223-1233, 2002.

E. Cerami, The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data, Cancer Discovery, vol.2, pp.401-404, 2012.

J. Pinheiro, D. Bates, S. Debroy, D. Sarkar, . &-r-core et al., , 2017.

J. Josse, M. Chavent, B. Liquet, and F. Husson, Handling Missing Values with Regularized Iterative Multiple Correspondence Analysis, Journal of Classification, vol.29, pp.91-116, 2012.
DOI : 10.1007/s00357-012-9097-0

URL : https://hal.archives-ouvertes.fr/hal-00647378

D. B. Rubin, Multiple Imputation for Nonresponse in Surveys. Wiley Series in Probability and Statistics, 1987.

S. Domcke, R. Sinha, D. A. Levine, C. Sander, and N. Schultz, Evaluating cell lines as tumour models by comparison of genomic profiles, Nature Communications, vol.4, p.2126, 2013.