A quantitative high resolution computational mechanics cell model for growing and regenerating tissues

Abstract : Mathematical models are increasingly designed to guide experiments in biology, biotechnology, as well as to assist in medical decision making. They are in particular important to understand emergent collective cell behavior. For this purpose, the models, despite still abstractions of reality, need to be quantitative in all aspects relevant for the question of interest. The focus in this paper is to study the regeneration of liver after drug-induced depletion of hepatocytes, in which surviving dividing and migrating hepatocytes must squeeze through a blood vessel network to fill the emerged lesions. Here, the cells' response to mechanical stress might significantly impact on the regener-ation process. We present a 3D high-resolution cell-based model integrating information from measurements in order to obtain a refined quantitative understanding of the cell-biomechanical impact on the closure of drug-induced lesions in liver. Our model represents each cell individually, constructed as a physically scalable network of viscoelastic elements, capable of mimicking realistic cell deformation and supplying information at subcellular scales. The cells have the capability to migrate, grow and divide, and infer the nature of their mechanical elements and their parameters from comparisons with optical stretcher experiments. Due to triangulation of the cell surface, interactions of cells with arbitrarily shaped (triangulated) structures such as blood vessels can be captured naturally. Comparing our simulations with those of so-called center-based models, in which cells have a rigid shape and forces are exerted
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https://hal.inria.fr/hal-01956023
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Submitted on : Friday, December 14, 2018 - 6:02:32 PM
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Paul Liedekerke, Johannes Neitsch, Tim Johann, Enrico Warmt, Ismael Gonzàlez-Valverde, et al.. A quantitative high resolution computational mechanics cell model for growing and regenerating tissues. 2018. ⟨hal-01956023v1⟩

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