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Sparklis over PEGASE Knowledge Graph: A New Tool for Pharmacovigilance

Abstract : Pharmacovigilance is in charge of studying the adverse effects of pharmaceutical products. In this field, pharmacovigilance specialists experience several difficulties when searching and exploring their patient data despite the existence of standardized terminologies (MedDRA). In this paper, we present our approach to enhance the way pharmacovigilance specialists perform search and exploration on their data. First, we have developed a knowledge graph that relies on the OntoADR ontology to semantically enrich the MedDRA terminology with SNOMED CT concepts, and that includes anonymized patient data from FAERS 3. Second, we have chosen and extended a semantic search tool, Sparklis, according to the user requirements that we have identified in pharmacovigilance. We report the results of a usability evaluation that has been performed by human factors specialists to check the benefits of our proposal.
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Submitted on : Thursday, January 10, 2019 - 12:05:55 PM
Last modification on : Wednesday, November 3, 2021 - 6:35:58 AM


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  • HAL Id : hal-01976825, version 1


Carlos Bobed, Laura Douze, Sébastien Ferré, Romaric Marcilly. Sparklis over PEGASE Knowledge Graph: A New Tool for Pharmacovigilance. International Conference on Semantic Web Applications and Tools for Life Sciences (SWAT4HCLS), Dec 2018, Antwerpen, Belgium. ⟨hal-01976825⟩



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