Numerical Workflow of Irreversible Electroporation for Deep-Seated Tumor

Olivier Gallinato 1 Baudouin Denis de Senneville 1 Olivier Seror 2 Clair Poignard 1
1 MONC - Modélisation Mathématique pour l'Oncologie
IMB - Institut de Mathématiques de Bordeaux, Inria Bordeaux - Sud-Ouest, Institut Bergonié - CRLCC Bordeaux
Abstract : The paper provides a numerical workflow, based on the “real-life” clinical workflow of irreversible electroporation (IRE) performed for the treatment of deep-seated liver tumors. Thanks to a combination of numerical modeling, image registration algorithm and clinical data, our numerical workflow enables to provide the distribution of the electric field as effectively delivered by the clinical IRE procedure. As a proof of concept, we show on a specific clinical case of IRE ablation of liver tumor that clinical data could be advantageously combined to numerical simulations in a near future, in order to give to the interventional radiologists information on the effective IRE ablation. We also corroborate the simulated treated region with the post-treatment MRI performed 3 days after the treatment
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Olivier Gallinato, Baudouin Denis de Senneville, Olivier Seror, Clair Poignard. Numerical Workflow of Irreversible Electroporation for Deep-Seated Tumor. Physics in Medicine and Biology, IOP Publishing, 2019, 64 (5), pp.055016. ⟨10.1088/1361-6560/ab00c4⟩. ⟨hal-02063020⟩

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