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Sparsity-based blind deconvolution of neural activation signal in fMRI
Abstract : The estimation of the hemodynamic response function (HRF) in functional magnetic resonance imaging (fMRI) is critical to deconvolve a time-resolved neural activity and get insights on the underlying cognitive processes. Existing methods propose to estimate the HRF using the experimental paradigm (EP) in task fMRI as a surrogate of neural activity. These approaches induce a bias as they do not account for laten-cies in the cognitive responses compared to EP and cannot be applied to resting-state data as no EP is available. In this work, we formulate the joint estimation of the HRF and neu-ral activation signal as a semi blind deconvolution problem. Its solution can be approximated using an efficient alternate minimization algorithm. The proposed approach is applied to task fMRI data for validation purpose and compared to a state-of-the-art HRF estimation technique. Numerical experiments suggest that our approach is competitive with others while not requiring EP information.
Cited literature [25 references]
https://hal.inria.fr/hal-02085810
Contributor : Philippe Ciuciu <>
Submitted on : Monday, April 1, 2019 - 1:50:31 PM
Last modification on : Monday, February 10, 2020 - 6:13:44 PM
Document(s) archivé(s) le : Tuesday, July 2, 2019 - 1:47:10 PM
Contributor : Philippe Ciuciu <>
Submitted on : Monday, April 1, 2019 - 1:50:31 PM
Last modification on : Monday, February 10, 2020 - 6:13:44 PM
Document(s) archivé(s) le : Tuesday, July 2, 2019 - 1:47:10 PM
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