, Life history trade-offs in cancer evolution, Nature Rev. Cancer, vol.13, pp.883-892, 2013.
DOI : 10.1038/nrc3606
URL : https://cloudfront.escholarship.org/dist/prd/content/qt4bb016sz/qt4bb016sz.pdf?t=ousgps
, Cancer across the tree of life: cooperation and cheating in multicellularity, Phil. Trans. R. Soc. B, vol.370, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02006447
, Evolution of cancer cell populations under cytotoxic therapy and treatment optimisation: insight from a phenotype-structured model, ESAIM Math. Model. Numer. Anal, 2018.
, Investigating prostate cancer tumourstroma interactions: clinical and biological insights from an evolutionary game, British Journal of Cancer, vol.106, issue.1, pp.174-181, 2011.
DOI : 10.1038/bjc.2011.517
URL : https://www.nature.com/articles/bjc2011517.pdf
, Optimisation of time-scheduled regimen for anti-cancer drug infusion, ESAIM Math. Model. Numer. Anal, vol.39, issue.6, pp.1069-1086, 2005.
DOI : 10.1051/m2an:2005052
URL : https://www.esaim-m2an.org/articles/m2an/pdf/2005/06/m2an0521.pdf
, Invasion fronts with variable motility: Phenotype selection, spatial sorting and wave acceleration, C. R. Acad. Sci. Paris, Ser. I, pp.761-766, 2012.
DOI : 10.1016/j.crma.2012.09.010
URL : https://hal.archives-ouvertes.fr/hal-00716349
, The origins of malignant tumors, 1929.
, Essential Mathematical Biology, 2003.
, Structure of Intratumor Heterogeneity: Is Cancer Hedging Its Bets? arXiv, 2013.
, Circulating tumor cells in clinical research and monitoring patients with colorectal cancer, Oncotarget, vol.9, issue.36, pp.24561-24571, 2018.
, Ancestral gene regulatory networks drive cancer, vol.114, pp.6160-6162, 2017.
, Optimization of an in vitro chemotherapy to avoid resistant tumours, J. Theor. Biol, vol.413, pp.24-33, 2017.
, Emergence of drug tolerance in cancer cell populations: an evolutionary outcome of selection, non-genetic instability and stress-induced adaptation, Cancer Research, vol.75, issue.6, pp.930-939, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01111271
, Cell population heterogeneity and evolution towards drug resistance in cancer: Biological and mathematical assessment, theoretical treatment optimisation, Biochem. Biophys. Acta, vol.1860, pp.2627-2645, 2016.
, Effects of an advection term in nonlocal Lotka-Volterra equations, Comm. Math. Sciences, vol.14, pp.1181-1188, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01237529
, Modeling continuous levels of resistance to multidrug therapy in cancer, Appl. Math. Model, vol.64, pp.733-751, 2018.
, Modeling the chemotherapy-induced selection of drug-resistant traits during tumor growth, J. Theor. Biol, vol.436, issue.7, pp.120-134, 2018.
, Cancer associated fibroblasts: the dark side of the coin, Am. J. Cancer Research, vol.1, issue.4, pp.482-497, 2011.
, Ancient genes establish stressinduced mutation as a hallmark of cancer, PLoS One, vol.12, issue.4, p.176258, 2017.
, Physiologically structured cell population dynamic models with applications to combined drug delivery optimisation in oncology, Mathematical Modelling of Natural Phenomena, vol.11, issue.6, pp.45-70, 2016.
URL : https://hal.archives-ouvertes.fr/hal-00750633
, Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers, Nature Lett, vol.508, pp.113-117, 2014.
, Optimal chemical control of populations developing drug resistance, Mathematical Medicine and Biology, vol.9, issue.3, pp.215-226, 1992.
, Cancer tumors as metazoa 1.0: tapping genes of ancient ancestors, Phys. Biol, vol.8, issue.1, p.15001, 2011.
, On selection dynamics for continuous structured populations, Commun. Math. Sci, vol.6, issue.3, pp.729-747, 2008.
URL : https://hal.archives-ouvertes.fr/hal-00363138
, Clonal evolution in relapsed acute myeloid leukaemia revealed by whole genome sequencing, Nature, vol.481, pp.506-510, 2012.
, Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion, Cancer Research, issue.7, pp.2455-2465, 2011.
DOI : 10.1158/0008-5472.can-10-3323
URL : https://hal.archives-ouvertes.fr/inserm-00819288
, Biology, molecular and organismic, vol.4, pp.443-452, 1964.
, An ancient evolutionary origin of genes associated with human genetic diseases, Mol. Biol. Evol, vol.25, issue.12, pp.2699-2707, 2008.
, Phylostratigraphic tracking of cancer genes suggests a link to the emergence of multicellularity in metazoa, BMC Biol, vol.8, issue.1, p.66, 2010.
, Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance, Molecular Cell, vol.54, pp.716-727, 2014.
DOI : 10.1016/j.molcel.2014.05.015
URL : https://doi.org/10.1016/j.molcel.2014.05.015
, Epigenetic modulators, modifiers and mediators in cancer aetiology and progression, Nature Rev. Genet, vol.17, issue.5, pp.284-99, 2016.
DOI : 10.1038/nrg.2016.13
URL : http://europepmc.org/articles/pmc4888057?pdf=render
, Adaptive therapy, Cancer Research, vol.69, issue.11, pp.4894-4903, 2009.
URL : https://hal.archives-ouvertes.fr/hal-01887358
, Intratumor heterogeneity and branched evolution revealed by multiregion sequencing, N Engl J Med, vol.366, issue.10, pp.883-892, 2012.
, How darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine, Br J Cancer, vol.103, issue.8, pp.1139-1143, 2010.
DOI : 10.1038/sj.bjc.6605912
URL : https://www.nature.com/articles/6605912.pdf
, Evolutionary dynamics of carcinogenesis and why targeted therapy does not work, Nature Rev. Cancer, vol.12, issue.7, pp.487-493, 2012.
DOI : 10.1038/nrc3298
URL : http://europepmc.org/articles/pmc4122506?pdf=render
, Integrating Biological and Mathematical Models to Explain and Overcome Drug Resistance in Cancer, Part 1: Biological Facts and Studies in Drug Resistance, Current Stem Cell Reports, vol.3, pp.253-259, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01574685
, Integrating Biological and Mathematical Models to Explain and Overcome Drug Resistance in Cancer, Part 2: From Theoretical Biology to Mathematical Models, Current Stem Cell Reports, vol.3, pp.260-268, 2017.
DOI : 10.1007/s40778-017-0098-0
URL : https://hal.archives-ouvertes.fr/hal-01558479
, Mechanisms of cancer drug resistance, Annu Rev Med, vol.53, pp.615-627, 2002.
, Cancer stem cells: back to Darwin?, Semin Cancer Biol, vol.20, issue.2, pp.65-70, 2010.
DOI : 10.1016/j.semcancer.2010.03.002
, Clonal evolution in cancer, Nature, vol.481, issue.7381, pp.306-313, 2012.
, Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia, Nature Comm, vol.7, p.12475, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01358183
, Adaptation to Stochastic Temporal Variations in Intratumoral Blood Flow: The Warburg Effect as a Bet Hedging Strategy, Bull Math Biol, vol.80, issue.5, pp.954-970, 2017.
, Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure, Cancer Cell, vol.32, pp.221-237, 2017.
, Bifurcation dynamics in lineagecommitment in bipotent progenitor cells, Dev Biol, vol.305, issue.2, pp.695-713, 2007.
, On the intrinsic inevitability of cancer: From foetal to fatal attraction, Sem. Canc. Biol, vol.21, pp.183-199, 2011.
, Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells, Canc. Metastasis Rev, vol.32, pp.423-448, 2013.
, Tumour progression: random mutations or an integrated survival response to cellular stress conserved from unicellular organisms?, J. Theor. Biol, vol.178, issue.4, pp.375-380, 1996.
DOI : 10.1006/jtbi.1996.0033
, On selection dynamics for competitive interactions, J. Math. Biol, vol.63, pp.493-551, 2011.
DOI : 10.1007/s00285-010-0370-8
URL : https://hal.archives-ouvertes.fr/hal-00602077
, Evolution and tinkering, Science, vol.196, issue.4295, pp.1161-1166, 1977.
DOI : 10.1126/science.860134
, Control Theory Approach to Cancer Chemotherapy: Benefiting from Phase Dependence and Overcoming Drug Resistance, Tutorials in Mathematical Biosciences III, Avner Friedman, 2006.
, Clock mutants of drosophila melanogaster, Proc Natl Acad Sci, vol.68, pp.2112-2116, 1971.
, The role of cell density and intratumoral heterogeneity in multidrug resistance, Cancer Res, vol.73, issue.24, pp.7168-7175, 2013.
, On the role of tumor heterogeneity for optimal cancer chemotherapy, Networks & Heterogeneous Media, vol.14, issue.1, pp.131-147, 2019.
, Circulating tumor DNA detection: A potential tool for colorectal cancer management, Oncology Letters, vol.7, issue.2, pp.1409-1416, 2019.
, Targeting cancer's weaknesses (not its strengths): therapeutic strategies suggested by the atavistic model, Bioessays, vol.36, issue.9, pp.827-835, 2014.
DOI : 10.1002/bies.201400070
URL : http://europepmc.org/articles/pmc4282648?pdf=render
, Dissecting the dynamics of epigenetic changes in phenotype-structured populations exposed to fluctuating environments, Journal of Theoretical Biology, vol.386, pp.166-176, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01237890
, Tracking the evolution of cancer cell populations through the mathematical lens of phenotypestructured equations, Biology Direct, vol.11, p.43, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01355314
, Populational adaptive evolution, chemotherapeutic resistance and multiple anti-cancer therapies, ESAIM Math. Model. Numer. Anal, vol.47, issue.2, pp.377-399, 2013.
URL : https://hal.archives-ouvertes.fr/hal-00714274
, Modeling the effects of space structure and combination therapies on phenotypic heterogeneity and drug resistance in solid tumors, Bull. Math. Biol, vol.77, issue.1, pp.1-22, 2014.
URL : https://hal.archives-ouvertes.fr/hal-00921266
, Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancerstromal cell interactions, The Journal of pathology, vol.201, issue.2, pp.221-228, 2003.
, Intra-tumour heterogeneity: a looking glass for cancer?, Nature Rev. Cancer, vol.12, pp.323-334, 2012.
, Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity, Nature, vol.514, pp.54-58, 2014.
, Smith & Eös Szathmáry. The Major Transitions in Evolution, 1997.
, Plasticity of the neoplastic phenotype in vivo is regulated by epigenetic factors, Proc Natl Acad Sci, vol.95, issue.26, pp.15333-15338, 1998.
, Cooperation and conflict in the evolution of multicellularity, Heredity, vol.36, pp.1-7, 2001.
, Cooperation and conflict during evolutionary transitions in individuality, J. Evol. Biol, vol.19, pp.1406-1409, 2006.
, Life-history evolution and the origin of multicellularity, J. Theor. Biol, vol.239, pp.257-272, 2006.
, Origin of the Metazoan Immune System: Identification of the Molecules and Their Functions in Sponges, Integrative Comparative Biology, vol.43, pp.281-292, 2003.
, Mathematical biology, vol.2, 2002.
, Adaptive dynamics of hematopoietic stem cells and their supporting stroma: A model and mathematical analysis, 2019.
URL : https://hal.archives-ouvertes.fr/hal-01963820
, The clonal evolution of tumor cell populations, Science, vol.194, issue.4260, pp.23-28, 1976.
, Combination of direct methods and homotopy in numerical optimal control: application to the optimization of chemotherapy in cancer, Journal of Optimization Theory and Applications, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01568779
, Metronomic chemotherapy: new rationale for new directions, Nature Rev. Clin. Oncol, vol.7, issue.8, pp.455-465, 2010.
, Transport equations in biology, 2007.
, Parabolic equations in biology, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01423552
, Non-darwinian dynamics in therapyinduced cancer drug resistance, Nat. Commun, vol.4, p.2467, 2013.
, Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: 'What does not kill me strengthens me', Br J Cancer, vol.112, issue.11, pp.1725-1732, 2015.
, On the origin of cancer: Can we ignore coherence?, Progress in Biophysics and Molecular Biology, vol.106, issue.2, pp.380-390, 2011.
, Clonal cooperation, Nature, vol.508, pp.52-53, 2014.
, Modelling interactions between tumour cells and supporting adipocytes in breast cancer, Internship report available at, 2015.
, Asymptotic analysis and optimal control of an integro-differential system modelling healthy and cancer cells exposed to chemotherapy, J. Math. Pures Appl, vol.116, pp.268-308, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01416594
, Global stability with selection in integro-differential Lotka-Volterra systems modelling trait-structured populations, Journal of Biological Dynamics, vol.12, issue.1, pp.872-893, 2018.
URL : https://hal.archives-ouvertes.fr/hal-01470722
, Analysis, control and optimisation of PDEs, application to the biology and therapy of cancer, 2018.
, Coordination of circadian timing in mammals, Nature, vol.418, pp.935-941, 2002.
, Elevated serum cytokines correlated with altered behavior, serum cortisol rhythm, and dampened 24-hour rest-activity pattern in patients with metastatic colorectal cancer, Clinical Cancer Research, vol.11, pp.1757-1764, 2005.
, Optimal Control for Mathematical Models of Cancer Therapies, 2015.
, A web of circadian pacemakers, Cell, vol.111, pp.919-922, 2002.
, A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations, Cell, vol.141, issue.1, pp.69-80, 2010.
, Epigenetic drugs as immunomodulators for combination therapies in solid tumors, Pharmacology & Therapeutics, vol.142, pp.339-350, 2014.
, The somatic mutation theory of cancer: growing problems with the paradigm?, BioEssays, vol.26, issue.10, pp.1097-1107, 2004.
, Role of Optimal Control Theory in Cancer Chemotherapy, Mathematical Biosciences, vol.101, pp.237-284, 1990.
, Tumorigenesis: it takes a village, Nature Rev. Cancer, vol.15, pp.473-483, 2015.
, Rechallenge therapy and treatment holiday: different strategies in management of metastatic colorectal cancer, Journal of experimental & clinical cancer research, vol.32, issue.1, p.1, 2013.
, Oxygen-collagen priority and the early metazoan fossil record, Proc Natl Acad Sci, vol.65, issue.4, pp.781-788, 1970.
, Biochemical keys to the emergence of complex life, Life in the Universe, pp.297-305, 1981.
, Optimal control and applications to aerospace: some results and challenges, Journal of Optimization Theory and Applications, vol.154, pp.713-758, 2012.
, Altered interactions between unicellular and multicellular genes drive hallmarks of transformation in a diverse range of solid tumors, vol.114, pp.6406-6411, 2017.
, Mechanisms of tumor promotion: possible role of inhibited intercellular communication, Eur. J. Cancer Clin. Oncol, vol.23, issue.6, pp.599-601, 1987.
, Gap Junctional Intercellular Communication as a Biological "Rosetta Stone" in Understanding, in a Systems Biological Manner, Stem Cell Behavior, Mechanisms of Epigenetic Toxicology, Chemoprevention and Chemotherapy, J. Membrane Biol, vol.218, pp.93-100, 2007.
, A conceptual integration of extra-, intraand gap junctional-intercellular communication in the evolution of multi-cellularity and stem cells: how disrupted cell-cell communication during development can affect diseases later in life, Int. J. Stem Cell Res. Ther, vol.3, issue.1, p.21, 2016.
, Ecology and evolution of cancer, 2017.
, Cancer: a de-repression of a default survival program common to all cells?: a life-history perspective on the nature of cancer, Bioessays, vol.34, issue.1, pp.72-82, 2011.
, Cancer beyond speciation, Advances in cancer research, vol.112, pp.283-350, 2011.
DOI : 10.1016/b978-0-12-387688-1.00010-7
, Mutagenesis and mapping of a mouse gene, clock, essential for circadian behavior, Science, vol.264, pp.719-725, 1994.
, The strategies of the genes, George Allen & Unwin, 1957.
, Ancient hot and cold genes and chemotherapy resistance emergence, Proc. Nat. Acad. Sci. USA, vol.112, pp.10467-10472, 2015.
DOI : 10.1073/pnas.1512396112
URL : http://www.pnas.org/content/112/33/10467.full.pdf
, Phylostratigraphic analysis of tumor and developmental transcriptomes reveals relationship between oncogenesis, phylogenesis and ontogenesis, Converg. Sci. Phys. Oncol, vol.4, p.25002, 2018.