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Linking Allele-Specific Expression And Natural Selection In Wild Populations

Abstract : Allele-specific expression (ASE) is now a widely studied mechanism at cell, tissue and organism levels. However, population-level ASE and its evolutive impacts have still never been investigated. Here, we hypothesized a potential link between ASE and natural selection on the cosmopolitan copepod Oithona similis. We combined metagenomic and metatranscriptomic data from seven wild populations of the marine copepod O. similis sampled during the Tara Oceans expedition. We detected 587 single nucleotide variants (SNVs) under ASE and found a significant amount of 152 SNVs under ASE in at least one population and under selection across all the populations. This constitutes a first evidence that selection and ASE target more common loci than expected by chance, raising new questions about the nature of the evolutive links between the two mechanisms.
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Submitted on : Monday, September 2, 2019 - 10:12:11 AM
Last modification on : Tuesday, January 4, 2022 - 6:03:57 AM
Long-term archiving on: : Thursday, January 9, 2020 - 1:01:58 AM


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Romuald Laso-Jadart, Kevin Sugier, Emmanuelle Petit, Karine Labadie, Pierre Peterlongo, et al.. Linking Allele-Specific Expression And Natural Selection In Wild Populations. 2019. ⟨hal-02275928⟩



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