An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel, Journal of pharmacological and toxicological methods, vol.81, pp.251-262, 2016. ,
Cross-site reliability of human induced pluripotent stem-cell derived cardiomyocyte based safety assays using microelectrode arrays: Results from a blinded CiPA pilot study, Toxicological Sciences, p.110, 2018. ,
Proarrhythmia risk prediction using human induced pluripotent stem cell-derived cardiomyocytes, Journal of pharmacological sciences, vol.136, issue.4, pp.249-256, 2018. ,
Optimization of an in silico cardiac cell model for proarrhythmia risk assessment, Frontiers in Physiology, vol.8, p.616, 2017. ,
Safety pharmacology methods and regulatory considerations evolve together, 2018. ,
Improved Prediction of Drug-Induced Torsades de Pointes Through Simulations of Dynamics and Machine Learning Algorithms, Clinical Pharmacology & Therapeutics, vol.100, issue.4, pp.371-379, 2016. ,
Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity, Frontiers in physiology, vol.8, p.668, 2017. ,
Diagnostic ECG classification based on neural networks, Journal of Electrocardiology, vol.26, pp.75-79, 1993. ,
Support vector machine-based arrhythmia classification using reduced features of heart rate variability signal. Artificial intelligence in medicine, vol.44, pp.51-64, 2008. ,
A bi-domain model for describing ischemic myocardial D-C potentials. MIT, 1978. ,
Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation, PLoS computational biology, vol.7, issue.5, p.1002061, 2011. ,
Simulation of multiple ion channel block provides improved early prediction of compounds clinical torsadogenic risk, Cardiovascular research, vol.91, issue.1, pp.53-61, 2011. ,
Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials, British journal of pharmacology, vol.168, issue.3, pp.718-733, 2013. ,
URL : https://hal.archives-ouvertes.fr/hal-00764102
Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart. Progress in biophysics and molecular biology, vol.90, pp.414-443, 2006. ,
Identification of ion currents components generating field potential recorded in MEA from hiPSC-CM, IEEE Transactions on Biomedical Engineering, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01570341
SUNDIALS: Suite of nonlinear and differential/algebraic equation solvers, ACM Transactions on Mathematical Software (TOMS), vol.31, issue.3, pp.363-396, 2005. ,
Composite biomarkers derived from Micro-Electrode Array measurements and computer simulations improve the classification of drug-induced channel block, 2017. ,
URL : https://hal.archives-ouvertes.fr/hal-01570819
In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modelling and numerical simulations ,
URL : https://hal.archives-ouvertes.fr/hal-01562673
Assessment of testing methods for drug-induced repolarization delay and arrhythmias in an iPS cell-derived cardiomyocyte sheet: Multi-site validation study, Journal of pharmacological sciences, vol.124, issue.4, pp.494-501, 2014. ,
Role of sarcoplasmic reticulum calcium in development of secondary calcium rise and early afterdepolarizations in long QT syndrome rabbit model, PloS one, vol.10, issue.4, p.123868, 2015. ,
Adaptive control processes: a guided tour, vol.2045, 2015. ,
A review of feature selection techniques in bioinformatics, bioinformatics, vol.23, pp.2507-2517, 2007. ,
The CMA evolution strategy: a comparing review, Towards a new evolutionary computation, pp.75-102, 2006. ,
Determining input features for multilayer perceptrons, Neurocomputing, vol.7, issue.2, pp.111-121, 1995. ,
30 years of adaptive neural networks: perceptron, madaline, and backpropagation, Proceedings of the IEEE, vol.78, issue.9, pp.1415-1442, 1990. ,
Linear discriminant analysis-a brief tutorial. Institute for Signal and information Processing, vol.18, pp.1-8, 1998. ,
Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes. Biochemical and biophysical research communications, vol.497, pp.1135-1141, 2018. ,
MICE models: superior to the HERG model in predicting Torsade de, Pointes. Scientific reports, vol.3, 2013. ,
Microelectrode Array (MEA) Axion Biosystems ,
Loratadine blockade of K+ channels in human heart: comparison with terfenadine under physiological conditions, Journal of Pharmacology and Experimental Therapeutics, vol.292, issue.1, pp.261-264, 2000. ,
CSAHi study-2: validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes: assessment of reference compounds and comparison with non-clinical studies and clinical information, Regulatory Toxicology and Pharmacology, vol.88, pp.238-251, 2017. ,
The hERG potassium channel and hERG screening for drug-induced torsades de pointes, Pharmacology & therapeutics, vol.119, issue.2, pp.118-132, 2008. ,
Modeling type 3 long QT syndrome with cardiomyocytes derived from patient-specific induced pluripotent stem cells, International journal of cardiology, vol.168, issue.6, pp.5277-5286, 2013. ,
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine, Pharmacology research & perspectives, vol.3, issue.5, 2015. ,
Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells, Nature, vol.302, issue.5911, p.790, 1983. ,
Inhibition of calcium-induced calcium release from purified cardiac sarcoplasmic reticulum vesicles, Journal of Biological Chemistry, vol.259, issue.12, pp.7547-7553, 1984. ,
Kinetics of chlorpromazine block of sodium channels in single guinea pig cardiac myocytes, Journal of Pharmacology and Experimental Therapeutics, vol.248, issue.2, pp.605-613, 1989. ,
Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine, British journal of pharmacology, vol.148, issue.4, pp.499-509, 2006. ,
Bepridil block of cardiac calcium and sodium channels, Journal of Pharmacology and Experimental Therapeutics, vol.237, issue.1, pp.9-17, 1986. ,
Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action, British journal of pharmacology, vol.123, issue.1, pp.23-30, 1998. ,
Azimilide (NE-10064) Can Prolong or Shorten the Action Potential Duration in Canine Ventricular Myocytes: Dependence on Blockade of K, Ca, and Na Channels, Journal of cardiovascular electrophysiology, vol.8, issue.2, pp.184-198, 1997. ,
A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes, Journal of pharmacological and toxicological methods, vol.84, pp.111-127, 2017. ,
Mechanistic Model-Informed Proarrhythmic Risk Assessment of Drugs: Review of the CiPA Initiative and Design of a Prospective Clinical Validation Study, Clinical Pharmacology & Therapeutics, vol.103, issue.1, pp.54-66, 2018. ,
Automatic optimization of an in silico model of human iPSC derived cardiomyocytes recapitulating calcium handling abnormalities, Frontiers in physiology, vol.9, 2018. ,
The comprehensive in vitro proarrhythmia assay (CiPA) initiative-Update on progress, Journal of pharmacological and toxicological methods, vol.81, pp.15-20, 2016. ,
Textbook of therapeutics: drug and disease management ,
Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds, pp.97-111 ,
Haoyu and others International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment, Cell reports, pp.3582-3592 ,
NE-10064) Can Prolong or Shorten the Action Potential Duration in Canine Ventricular Myocytes: Dependence on Blockade of K, Ca, and Na Channels, Journal of cardiovascular electrophysiology, pp.184-198 ,