Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2019

Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids

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Anne Boland
Robert Olaso
Sandrine Boyault
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  • PersonId : 757688
  • IdRef : 075706466
Anne-Claire Toffart
  • Function : Author
  • PersonId : 855543
Marie Brevet
  • Function : Author
  • PersonId : 1202971

Abstract

The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary car-cinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low-and high-grade lung neuroendocrine neoplasms.
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hal-02339242 , version 1 (30-10-2019)

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Nicolas Alcala, Noémie Leblay, Aurélie Gabriel, Lise Mangiante, Davis Hervás, et al.. Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids. Nature Communications, 2019, 10 (1), pp.1-21. ⟨10.1038/s41467-019-11276-9⟩. ⟨hal-02339242⟩
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