Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids
(1)
,
(1)
,
(1)
,
(1)
,
(2)
,
(1)
,
(3)
,
(3)
,
(4)
,
(1)
,
(1)
,
(1)
,
(1)
,
(1)
,
(5)
,
(5)
,
(5)
,
(6, 7)
,
(1)
,
(1)
,
(1)
,
(3)
,
(4, 8)
,
(9)
,
(9)
,
(10)
,
(11)
,
(12)
,
(13)
,
(14)
,
(15)
,
(16)
,
(15)
,
(15)
,
(17)
,
(17)
,
(18)
,
(18)
,
(19)
,
(19)
,
(20)
,
(20)
,
(21)
,
(21)
,
(22)
,
(23)
,
(23)
,
(24)
,
(25)
,
(5)
,
(1)
,
(26)
,
(6, 7)
,
(27)
,
(4)
,
(18)
,
(18)
,
(24)
,
(28)
,
(28)
,
(29)
,
(2)
,
(29)
,
(9)
,
(4)
,
(29)
,
(30)
,
(1)
,
(1)
,
(1)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
Nicolas Alcala
- Function : Author
- PersonId : 778162
- ORCID : 0000-0002-5961-5064
Lise Mangiante
- Function : Author
- PersonId : 797840
- ORCID : 0000-0001-8309-0950
Davis Hervás
- Function : Author
- PersonId : 885358
Anne Boland
- Function : Author
- PersonId : 757786
- ORCID : 0000-0001-8789-5676
Robert Olaso
- Function : Author
- PersonId : 774936
- ORCID : 0000-0001-7631-9657
Catherine Voegele
- Function : Author
- PersonId : 771118
- IdRef : 193031205
Paul Hofman
- Function : Author
- PersonId : 760269
- ORCID : 0000-0003-0431-9353
- IdRef : 061092630
Vincent Thomas de Montpreville
- Function : Author
- PersonId : 797841
- ORCID : 0000-0001-7490-4000
Alain Viari
- Function : Author
- PersonId : 18170
- IdHAL : alain-viari
- ORCID : 0000-0002-1329-7777
- IdRef : 081478151
Christophe Caux
- Function : Author
- PersonId : 756262
- ORCID : 0000-0003-2438-833X
- IdRef : 08417854X
Hector Hernandez-Vargas
- Function : Author
- PersonId : 768730
- ORCID : 0000-0001-6045-2103
- IdRef : 175457689
Lynnette Fernandez-Cuesta
- Function : Author
- PersonId : 797842
- ORCID : 0000-0002-0724-6703
- IdRef : 233420819
Abstract
The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary car-cinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low-and high-grade lung neuroendocrine neoplasms.
Domains
Life Sciences [q-bio]
Origin : Files produced by the author(s)
Loading...