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Poster communications

A system-level computational model of decision-making and learning in the lateral and medial sub-regions of Orbitofrontal Cortex

Bhargav Teja Nallapu 1, 2, 3 Frédéric Alexandre 3
3 Mnemosyne - Mnemonic Synergy
LaBRI - Laboratoire Bordelais de Recherche en Informatique, Inria Bordeaux - Sud-Ouest, IMN - Institut des Maladies Neurodégénératives [Bordeaux]
Abstract : In the context of flexible and adaptive animal behavior, the orbitofrontal cortex (OFC) is found to be one of the crucial regions in the prefrontal cortex (PFC) influencing the downstream processes of decision-making and learning in the sub-cortical regions. Although OFC has been implicated to be important in a variety of related behavioral processes, the exact mechanisms are unclear, through which the OFC encodes or processes information related to decision-making and learning. Here, we propose a system-level view of the OFC, positioning it at the nexus of sub-cortical systems and other prefrontal systems. Particularly we focus on one of the most recent implications of neuroscientific evidences regarding the OFC - possible functional dissociation between two of its sub-regions : lateral and medial. We present a system-level computational model of decision-making and learning involving the two sub-regions taking into account their individual roles implicated in neuroscientific studies. We leverage well-known computational architecture of thalamo-cortical basal ganglia loops on a 3-arm bandit task with varying reward probabilities. We simulate lesions of lateral and medial OFC structures in the model to show differential effects in performance depending on the value difference of the presented options, thus accounting for the recent experimental findings about the dissociate functional roles of both the sub-regions.
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https://hal.inria.fr/hal-02417618
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Submitted on : Wednesday, December 18, 2019 - 12:09:01 PM
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Bhargav Teja Nallapu, Frédéric Alexandre. A system-level computational model of decision-making and learning in the lateral and medial sub-regions of Orbitofrontal Cortex. OFC 2019 : Fourth Quadrennial Meeting on OFC Function, Nov 2019, Paris, France. ⟨hal-02417618⟩

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