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Biochemical Threshold Function Implementation with Zero-Order Ultrasensitivity

Abstract : Engineering biochemical reactions is a key task in synthetic biology to enable biomedical and other applications. The biochemical threshold function is a crucial component in the biosensor circuits to be deployed in living cells or synthetic vesicles for disease diagnosis. In this work, based on the zero-order ultrasensitivity, we propose an economic biochemical implementation of threshold functions with reconfigurable threshold values. We show that the so-constructed threshold function module well approximates the unit step function and allows robust composition with other function modules for complex computation tasks.
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https://hal.inria.fr/hal-02425761
Contributor : François Fages <>
Submitted on : Tuesday, December 31, 2019 - 11:14:39 AM
Last modification on : Thursday, May 27, 2021 - 8:08:03 AM
Long-term archiving on: : Wednesday, April 1, 2020 - 1:04:36 PM

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Wei-Chih Huang, Jie-Hong Jiang, François Fages, Franck Molina. Biochemical Threshold Function Implementation with Zero-Order Ultrasensitivity. BioCAS 2019 - IEEE Biomedical Circuits and Systems Conference, Oct 2019, Nara, Japan. pp.1-4, ⟨10.1109/BIOCAS.2019.8919176⟩. ⟨hal-02425761⟩

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