Skip to Main content Skip to Navigation
Conference papers

No Structural Differences Are Revealed by VBM in 'de novo' Parkinsonian Patients

Verónica Muñoz Ramírez 1, 2 Florence Forbes 1 Pierrick Coupé 3 Michel Dojat 2
1 MISTIS - Modelling and Inference of Complex and Structured Stochastic Systems
Inria Grenoble - Rhône-Alpes, Grenoble INP - Institut polytechnique de Grenoble - Grenoble Institute of Technology, LJK - Laboratoire Jean Kuntzmann
Abstract : The identification of brain morphological alterations in newly diagnosed PD patients (i.e. ‘de novo’) could potentially serve as a biomarker and accelerate diagnosis. However, presently no consensus exists in the literature possibly due to several factors: small size cohorts, differences in segmentation techniques or bad control of false positive rates. In this study, we use the CAT12 pipeline, to seek for morphological brain differences in gray and white matter of 66 controls and 144 de novo PD patients from the PPMI database. Moreover, we search for subcortical structure differences using the VolBrain pipeline. We found no structural brain differences in this de novo Parkinsonian population, neither in tissues using a whole brain analysis nor in any of nine subcortical structures analyzed separately. We conclude that some results published in the literature may appear as false positives and we contest their reproductibility.
Complete list of metadata

Cited literature [18 references]  Display  Hide  Download
Contributor : Veronica Munoz Ramirez Connect in order to contact the contributor
Submitted on : Thursday, January 2, 2020 - 5:59:44 AM
Last modification on : Wednesday, November 3, 2021 - 7:49:53 AM
Long-term archiving on: : Friday, April 3, 2020 - 3:31:04 PM


Files produced by the author(s)



Verónica Muñoz Ramírez, Florence Forbes, Pierrick Coupé, Michel Dojat. No Structural Differences Are Revealed by VBM in 'de novo' Parkinsonian Patients. MEDINFO 2019 - 17th World Congress On Medical And Health Informatics, Aug 2019, Lyon, France. pp.268-272, ⟨10.3233/SHTI190225⟩. ⟨hal-02426273⟩



Record views


Files downloads