The emerging infrastructure of cyber-physical systems consisting of everyday items, as product’s packaging, and advanced digital communication devices opens a new digital dimension for interaction and user experience. Consequently, the concept of human-packaging interaction goes beyond the pragmatic aspects of physical packaging attributes, and, in turn, embraces the potentials of ICT systems. Due to the new forms of human-packaging interactive systems, designers have to address the relevancy of the interaction design and the complexity in the relationship between consumer behavior and interactive system design, i.e. digitally-enhanced packaging. Therefore this research aims to describe the digitally-enhanced packaging as a digital interactive system in regards to the theories of human-computer interaction, interaction design, and user-centered design. In this paper, the critical elements of the interactive packaging design are described. This study concludes that for the interactive systems to be effective and used, designers have to build not only a reward-based, intuitive and simple interaction design that would persuade users to take actions, but also they have to think of other mediate interactions, internal and external resources that are significant to reach the final aim.