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Article Dans Une Revue Journal of Investigative Dermatology Année : 2020

Polyomavirus-positive Merkel cell carcinoma derived from a trichoblastoma suggests an epithelial origin of this Merkel cell carcinoma

Eve Maubec
  • Fonction : Auteur
Bhavishya Sarma
Patricia Berthon
Annie Levy
  • Fonction : Auteur
Antoine Touzé
David Schrama
Roland Houben

Résumé

Merkel cell carcinoma (MCC), an aggressive neuroendocrine carcinoma of the skin, is to date the only human cancer known to be frequently caused by a polyomavirus. However, it is a matter of debate which cells are targeted by the Merkel cell polyomavirus (MCPyV) to give rise to the phenotypically multifaceted MCC cells. To assess the lineage of origin of MCPyV-positive MCC, genetic analysis of a very rare tumor combining benign trichoblastoma and MCPyV-positive MCC was conducted by massive parallel sequencing. Although MCPyV was found to be integrated only in the MCC part, six somatic mutations were shared by both tumor components. The mutational overlap between the trichoblastoma and MCPyV-positive MCC parts of the combined tumor implies that MCPyV integration occurred in an epithelial tumor cell before MCC development. Therefore, our report demonstrates that MCPyV-positive MCC can derive from the epithelial lineage.
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hal-02621965 , version 1 (20-05-2022)

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Paternité - Pas d'utilisation commerciale

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Thibault Kervarrec, Mohanad Aljundi, Silke Appenzeller, Mahtab Samimi, Eve Maubec, et al.. Polyomavirus-positive Merkel cell carcinoma derived from a trichoblastoma suggests an epithelial origin of this Merkel cell carcinoma. Journal of Investigative Dermatology, 2020, 140 (5), pp.976-985. ⟨10.1016/j.jid.2019.09.026⟩. ⟨hal-02621965⟩
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