Skip to Main content Skip to Navigation
Journal articles

Polyomavirus-positive Merkel cell carcinoma derived from a trichoblastoma suggests an epithelial origin of this Merkel cell carcinoma

Abstract : Merkel cell carcinoma (MCC), an aggressive neuroendocrine carcinoma of the skin, is to date the only human cancer known to be frequently caused by a polyomavirus. However, it is a matter of debate which cells are targeted by the Merkel cell polyomavirus (MCPyV) to give rise to the phenotypically multifaceted MCC cells. To assess the lineage of origin of MCPyV-positive MCC, genetic analysis of a very rare tumor combining benign trichoblastoma and MCPyV-positive MCC was conducted by massive parallel sequencing. Although MCPyV was found to be integrated only in the MCC part, six somatic mutations were shared by both tumor components. The mutational overlap between the trichoblastoma and MCPyV-positive MCC parts of the combined tumor implies that MCPyV integration occurred in an epithelial tumor cell before MCC development. Therefore, our report demonstrates that MCPyV-positive MCC can derive from the epithelial lineage.
Complete list of metadata

https://hal.inrae.fr/hal-02621965
Contributor : Accord Elsevier CCSD Connect in order to contact the contributor
Submitted on : Friday, May 20, 2022 - 10:25:41 AM
Last modification on : Friday, May 20, 2022 - 10:25:42 AM

File

S0022202X19333871.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

Identifiers

Citation

Thibault Kervarrec, Mohanad Aljundi, Silke Appenzeller, Mahtab Samimi, Eve Maubec, et al.. Polyomavirus-positive Merkel cell carcinoma derived from a trichoblastoma suggests an epithelial origin of this Merkel cell carcinoma. Journal of Investigative Dermatology, Nature Publishing Group, 2020, 140 (5), pp.976-985. ⟨10.1016/j.jid.2019.09.026⟩. ⟨hal-02621965⟩

Share

Metrics

Record views

41

Files downloads

0