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Chemo-enzymatic synthesis of glycolipids, their polymerization and self-assembly

Dounia Arcens 1, 2 Gaëlle Le Fer 3 Etienne Grau 2 Stéphane Grelier 2 Henri Cramail 2 Frédéric Peruch 1
1 Team 1 LCPO : Polymerization Catalyses & Engineering
LCPO - Laboratoire de Chimie des Polymères Organiques
2 Team 2 LCPO : Biopolymers & Bio-sourced Polymers
LCPO - Laboratoire de Chimie des Polymères Organiques
3 Team 3 LCPO : Polymer Self-Assembly & Life Sciences
LCPO - Laboratoire de Chimie des Polymères Organiques
Abstract : This paper describes the synthesis of bio-based methacrylated 12-hydroxystearate glucose (MASG), and its (co)polymerization with methyl methacrylate (MMA) by either free-or RAFT radical polymerizations. The obtained amphiphilic p(MMA-MASG) copolymers self-assembled in water into various morphologies depending on the MASG unit content and glycopolymer crystallinity. Finally, as a proof of concept, a hydrophobic dye, Nile Red, was entrapped by co-nanoprecipitation into p(MMA-MASG) nanoparticles, showing their loading capacity and thus demonstrating the potential of such amphiphilic glycolipid-based copolymers in hydrophobic compound encapsulation applications.
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Submitted on : Tuesday, June 30, 2020 - 12:34:26 PM
Last modification on : Tuesday, June 30, 2020 - 12:48:25 PM

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Dounia Arcens, Gaëlle Le Fer, Etienne Grau, Stéphane Grelier, Henri Cramail, et al.. Chemo-enzymatic synthesis of glycolipids, their polymerization and self-assembly. Polymer Chemistry, Royal Society of Chemistry - RSC, 2020, 11 (24), pp.3994-4004. ⟨10.1039/D0PY00526F⟩. ⟨hal-02882238⟩

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