, However the causes of ketamine-710 induced cortical segmentation are not explained by our model, and remain an enigma

, These meta-stable states are spatial patterns that are 717 activated in a specific temporal sequence. Since meta-stable states require specific non-718 homogeneous network interactions (49) while the present model network is homogeneous, such 719 meta-stable states are not solutions of our model, The proposed spiking population model and the derived mean-field model consider homogeneous 713 spatial neural populations

, To our best knowledge, the present study is one of the first to involve the AAS 725 demonstrating its importance. We have considered both frontal and occipital cortical areas, but 726 have neglected other brain areas that are known to exhibit diverse anaesthetic impact. Examples 727 are the parietal cortex and the areas of the default mode network that respond differently at 728 different anaesthetic depths (52,54), Previous network studies of coupled individual neurons have also reproduced qualitatively frontal 722 and EEG (8) and anteriorisation (50) by considering anaesthetic effects in individual neurons

, All authors designed the study, analysed the data, and wrote the paper

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