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A Family of Tree-Based Generators for Bubbles in Directed Graphs

Abstract : Bubbles are pairs of internally vertex-disjoint (s, t)-paths in a directed graph. In de Bruijn graphs built from reads of RNA and DNA data, bubbles represent interesting biological events, such as alternative splicing (AS) and allelic differences (SNPs and indels). However, the set of all bubbles in a de Bruijn graph built from real data is usually too large to be efficiently enumerated and analysed in practice. In particular, despite significant research done in this area, listing bubbles still remains the main bottleneck for tools that detect AS events in a reference-free context. Recently, in [1] the concept of a bubble generator was introduced as a way for obtaining a compact representation of the bubble space of a graph. Although this generator was quite effective in finding AS events, preliminary experiments showed that it is about 5 times slower than state-of-art methods. In this paper we propose a new family of bubble generators which improve substantially on the previous generator: generators in this new family are about two orders of magnitude faster and are still able to achieve similar precision in identifying AS events. To highlight the practical value of our new generators, we also report some experimental results on a real dataset.
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https://hal.inria.fr/hal-02971154
Contributor : Marie-France Sagot <>
Submitted on : Monday, October 19, 2020 - 11:48:35 AM
Last modification on : Tuesday, October 20, 2020 - 3:37:24 AM

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Vicente Acuña, Leandro Soares de Lima, Giuseppe Italiano, Luca Sciarria, Marie-France Sagot, et al.. A Family of Tree-Based Generators for Bubbles in Directed Graphs. International Workshop on Combinatorial Algorithms (IWOCA 2020), 2020, Bordeaux, France. pp.17-29, ⟨10.1007/978-3-030-48966-3_2⟩. ⟨hal-02971154⟩

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