High-resolution multi-T-1-weighted contrast and T(1)mapping with lowB1>+sensitivity using the fluid and white matter suppression (FLAWS) sequence at 7T - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Magnetic Resonance in Medicine Année : 2021

High-resolution multi-T-1-weighted contrast and T(1)mapping with lowB1>+sensitivity using the fluid and white matter suppression (FLAWS) sequence at 7T

Résumé

Purpose - To demonstrate that fluid and white matter suppression (FLAWS) imaging can be used for high-resolution T mapping with low transmitted bias field ( ) sensitivity at 7T. Methods - The FLAWS sequence was optimized for 0.8-mm isotropic resolution imaging. The theoretical accuracy and precision of the FLAWS T mapping was compared with the one of the magnetization-prepared two rapid gradient echoes (MP2RAGE) sequence optimized for low sensitivity. FLAWS images were acquired at 7T on six healthy volunteers (21 to 48 years old; two women). MP2RAGE and saturation-prepared with two rapid gradient echoes (SA2RAGE) datasets were also acquired to obtain T mapping references and maps. The contrast-to-noise ratio (CNR) between brain tissues was measured in the FLAWS-hco and MP2RAGE-uni images. The Pearson correlation was measured between the MP2RAGE and FLAWS T maps. The effect of on FLAWS T mapping was assessed using the Pearson correlation. Results - The FLAWS-hco images were characterized by a higher brain tissue CNR ( , , ) than the MP2RAGE-uni images ( , , ). The theoretical accuracy and precision of the FLAWS T mapping ( ) were in agreement with those provided by the MP2RAGE T mapping ( ). A good agreement was found between in vivo T values measured with the MP2RAGE and FLAWS sequences (r = 0.91). A weak correlation was found between the FLAWS T map and the map within cortical gray matter and white matter segmentations ( ; ). Conclusion - The results from this study suggest that FLAWS is a good candidate for high-resolution T -weighted imaging and T mapping at the field strength of 7T.
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Dates et versions

hal-02992430 , version 1 (06-11-2020)

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Jérémy Beaumont, Giulio Gambarota, Hervé Saint-Jalmes, Oscar Acosta, Jean-Christophe Ferré, et al.. High-resolution multi-T-1-weighted contrast and T(1)mapping with lowB1>+sensitivity using the fluid and white matter suppression (FLAWS) sequence at 7T. Magnetic Resonance in Medicine, 2021, 85 (3), pp.1364-1378. ⟨10.1002/mrm.28517⟩. ⟨hal-02992430⟩
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