Nonlinear Spatiotemporal Viral Infection Model with CTL Immunity: Mathematical Analysis - Inria - Institut national de recherche en sciences et technologies du numérique Accéder directement au contenu
Article Dans Une Revue Mathematics Année : 2020

Nonlinear Spatiotemporal Viral Infection Model with CTL Immunity: Mathematical Analysis

Résumé

A mathematical model describing viral dynamics in the presence of the latently infected cells and the cytotoxic T-lymphocytes cells (CTL), taking into consideration the spatial mobility of free viruses, is presented and studied. The model includes five nonlinear differential equations describing the interaction among the uninfected cells, the latently infected cells, the actively infected cells, the free viruses, and the cellular immune response. First, we establish the existence, positivity, and boundedness for the suggested diffusion model. Moreover, we prove the global stability of each steady state by constructing some suitable Lyapunov functionals. Finally, we validated our theoretical results by numerical simulations for each case.

Dates et versions

hal-03029312 , version 1 (28-11-2020)

Identifiants

Citer

Jaouad Danane, Karam Allali, Leon Tine, Vitaly Volpert. Nonlinear Spatiotemporal Viral Infection Model with CTL Immunity: Mathematical Analysis. Mathematics , 2020, 8 (1), pp.1-13. ⟨10.3390/math8010052⟩. ⟨hal-03029312⟩
42 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More