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Reconstructing Genotypes in Private Genomic Databases from Genetic Risk Scores

Abstract : Some organisations like 23andMe and the UK Biobank have large genomic databases that they re-use for multiple different genomewide association studies (GWAS). Even research studies that compile smaller genomic databases often utilise these databases to investigate many related traits. It is common for the study to report a genetic risk score (GRS) model for each trait within the publication. Here we show that under some circumstances, these GRS models can be used to recover the genetic variants of individuals in these genomic databases—a reconstruction attack. In particular, if two GRS models are trained using a largely overlapping set of participants, then it is often possible to determine the genotype for each of the individuals who were used to train one GRS model, but not the other. We demonstrate this theoretically and experimentally by analysing the Cornell Dog Genome database. The accuracy of our reconstruction attack depends on how accurately we can estimate the rate of co-occurrence of pairs of SNPs within the private database, so if this aggregate information is ever released, it would drastically reduce the security of a private genomic database. Caution should be applied when using the same database for multiple analysis, especially when a small number of individuals are included or excluded from one part of the study.
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https://hal.inria.fr/hal-03100032
Contributor : Aurélien Bellet <>
Submitted on : Wednesday, January 6, 2021 - 2:20:17 PM
Last modification on : Thursday, January 7, 2021 - 3:39:11 AM

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2020.01.15.907808v1.full.pdf
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Brooks Paige, James Bell, Aurélien Bellet, Adrià Gascón, Daphne Ezer. Reconstructing Genotypes in Private Genomic Databases from Genetic Risk Scores. 24th International Conference On Research In Computational Molecular Biology (RECOMB 2020), 2020, Virtual, Italy. ⟨10.1101/2020.01.15.907808⟩. ⟨hal-03100032⟩

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