Skip to Main content Skip to Navigation
Journal articles

Bayesian mixture models for cytometry data analysis

Abstract : Bayesian mixture models are increasingly used for model‐based clustering and the follow‐up analysis on the clusters identified. As such, they are of particular interest for analyzing cytometry data where unsupervised clustering and association studies are often part of the scientific questions. Cytometry data are large quantitative data measured in a multidimensional space that typically ranges from a few dimensions to several dozens, and which keeps increasing due to innovative high‐throughput biotechonologies. We present several recent parametric and nonparametric Bayesian mixture modeling approaches, and describe advantages and limitations of these models under different research context for cytometry data analysis. We also acknowledge current computational challenges associated with the use of Bayesian mixture models for analyzing cytometry data, and we draw attention to recent developments in advanced numerical algorithms for estimating large Bayesian mixture models, which we believe have the potential to make Bayesian mixture model more applicable to new types of single‐cell data with higher dimensions.
Complete list of metadatas

https://hal.inria.fr/hal-03100447
Contributor : Boris Hejblum <>
Submitted on : Thursday, January 7, 2021 - 7:20:40 PM
Last modification on : Monday, January 11, 2021 - 1:45:42 PM

File

Bayesian_Mixture_Cytometry_WIR...
Files produced by the author(s)

Identifiers

Collections

Citation

Lin Lin, Boris Hejblum. Bayesian mixture models for cytometry data analysis. Wiley Interdisciplinary Reviews: Computational Statistics, Wiley, 2020, ⟨10.1002/wics.1535⟩. ⟨hal-03100447⟩

Share

Metrics

Record views

11

Files downloads

44