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Conference Papers Year : 2020

Qualitative Analysis of Mammalian Circadian Oscillations: Cycle Dynamics and Robustness

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Abstract

In asynchronous Boolean models, periodic solutions are represented by terminal strongly connected graphs, which are typically composed of hundreds of states and transitions. For biological systems, it becomes a challenging task to compare such mathematical objects with biological knowledge, or interpret the transitions inside an attractor in terms of the sequence of events in a biological cycle. A recent methodology generates summary graphs to help visualizing complex asynchronous attractors and order the dynamic progression based on known biological data. In this article we apply this method to a Boolean model of the mammalian circadian clock, for which the summary graph recovers the main phases of the cycle, in the expected order. It also provides a detailed view of the attractor, suggesting improvements in the design of the model's logical rules and highlighting groups of transitions that are essential for the attractor's robustness.
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hal-03105583 , version 1 (11-01-2021)

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Ousmane Diop, Madalena Chaves, Laurent Tournier. Qualitative Analysis of Mammalian Circadian Oscillations: Cycle Dynamics and Robustness. CMSB 2020 - 18th International Conference on Computational Methods in Systems Biology, Sep 2020, Konstanz, Germany. pp.176-192, ⟨10.1007/978-3-030-60327-4_10⟩. ⟨hal-03105583⟩
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