Previous studies indicate that hybrid robotic rehabilitation systems (HRRS) may be more effective in improving motor control and functional skills compared to robotic therapy alone in patients with hemiparesis after chronic stroke and compared to traditional physical therapy in individuals with acute stroke. However, although studies prove the potential benefit of this technology, few randomized controlled trials have been conducted so far and no systematic literature review has been carried out. Systematic reviews are necessary because it is the most appropriate and current method for summarizing and synthesizing evidences about the effectiveness and effects of interventions. Therefore, this project investigates systematically the effects of HRRS on central injuries upper limb recovery based on each of the International Classification of Functioning, Disability and Health (ICF) domains. This study contributes to the development of new hybrid neuroprostheses that are proven to be effective for upper limb rehabilitation.This systematic review is done with the participation of physicians, occupational therapists and engineers.